EP 2946790 A3 20160224 - MIMOTOPES OF ALPHA-SYNUCLEIN AND VACCINES THEREOF FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS
Title (en)
MIMOTOPES OF ALPHA-SYNUCLEIN AND VACCINES THEREOF FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS
Title (de)
MIMOTOPE VON ALPHA-SYNUCLEIN UND IMPFSTOFFE DAFÜR ZUR BEHANDLUNG VON NEURODEGENERATIVEN ERKRANKUNGEN
Title (fr)
MIMOTOPES DE L'ALPHA-SYNUCLEINE ET LES VACCINS DE CELLE-CI POUR LE TRAITEMENT DES MALADIES NEURODEGENERATIVES
Publication
Application
Priority
- AT 2972008 A 20080222
- EP 09712380 A 20090223
Abstract (en)
[origin: WO2009103105A2] The present invention relates to the use of at least one compound comprising the amino acid sequence: (X1)nX2X3PVX4X5X6(X7)m (Formula I), wherein X1 is any amino acid residue, X2 is an amino acid residue selected from the group consist ing of aspartic acid (D) and glutamic acid (E), X3 is any amino acid residue, X4 is any amino acid residue, X5 is an amino acid residue selected from the group consisting of proline (P) and alanine (A), X6 is an amino acid residue selected from the group consisting of aspartic acid (D) and glutamic acid (E), X7 is any amino acid residue, n and m, independently, are 0 or an integer of more than 0, and wherein the amino acid sequence according to Formula I is not identical with, or does not comprise the 8-mer polypeptide fragment of alpha-synuclein having the amino acid sequence DMPVDPDN, said compound having a binding capacity to an antibody which is specific for an epitope of alpha-synuclein comprising the amino acid sequence DMPVDPDN for producing a medicament for preventing and/or treating synucleinopathies.
IPC 8 full level
A61K 39/00 (2006.01); A61K 38/08 (2006.01); A61P 25/00 (2006.01); C07K 7/06 (2006.01)
CPC (source: CN EP KR US)
A61K 9/0019 (2013.01 - US); A61K 38/08 (2013.01 - KR); A61K 38/10 (2013.01 - KR); A61K 38/1709 (2013.01 - EP US); A61K 39/0007 (2013.01 - CN EP US); A61K 39/385 (2013.01 - CN); A61K 39/39 (2013.01 - KR); A61K 47/02 (2013.01 - US); A61K 47/643 (2017.08 - EP KR US); A61P 25/00 (2018.01 - EP); A61P 25/02 (2018.01 - EP); A61P 25/14 (2018.01 - EP); A61P 25/16 (2018.01 - EP KR); A61P 25/28 (2018.01 - EP KR); C07K 7/06 (2013.01 - CN); C07K 14/47 (2013.01 - US); C07K 16/4241 (2013.01 - EP US); A61K 9/0053 (2013.01 - US); A61K 31/00 (2013.01 - US); A61K 38/00 (2013.01 - EP US); A61K 39/385 (2013.01 - US); A61K 39/3955 (2013.01 - US); A61K 47/42 (2013.01 - US); A61K 47/6911 (2017.08 - US); A61K 2039/505 (2013.01 - US); A61K 2039/55505 (2013.01 - CN KR US); A61K 2039/55516 (2013.01 - US); A61K 2039/55555 (2013.01 - US); A61K 2039/55566 (2013.01 - EP US); A61K 2039/55572 (2013.01 - US); A61K 2039/57 (2013.01 - US); A61K 2039/575 (2013.01 - US); A61K 2039/58 (2013.01 - US); A61K 2039/6031 (2013.01 - EP US); A61K 2039/6081 (2013.01 - CN US); A61K 2039/70 (2013.01 - US); A61P 25/16 (2018.01 - US); A61P 25/28 (2018.01 - US); C07K 7/06 (2013.01 - US); C07K 7/08 (2013.01 - US); C07K 16/18 (2013.01 - US); C07K 2317/21 (2013.01 - US); C07K 2317/32 (2013.01 - US); C07K 2317/33 (2013.01 - US); C07K 2317/622 (2013.01 - EP US); C07K 2317/76 (2013.01 - US); C07K 2319/00 (2013.01 - US); G01N 33/6896 (2013.01 - US); G01N 2800/52 (2013.01 - US)
Citation (search report)
- [A] WO 2006045037 A2 20060427 - ELAN PHARM INC [US], et al
- [AD] WO 2004041067 A2 20040521 - ELAN PHARM INC [US], et al
- [A] JAKES R ET AL: "Epitope Mapping of LB509, a Monocional Directed Against Human alpha-Synuclein", NEUROSCIENCE LETTERS, LIMERICK, IE, vol. 269, 1 July 1999 (1999-07-01), pages 13 - 16, XP003016505, ISSN: 0304-3940
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA RS
DOCDB simple family (publication)
WO 2009103105 A2 20090827; WO 2009103105 A3 20091210; AT 506535 A1 20090915; AT 506535 B1 20100415; AU 2009217216 A1 20090827; AU 2009217216 B2 20130523; BR PI0908097 A2 20151201; CA 2716007 A1 20090827; CA 2716007 C 20190903; CN 101969989 A 20110209; CN 101969989 B 20191210; CN 105250999 A 20160120; CN 105250999 B 20221021; CN 107261133 A 20171020; CN 116327905 A 20230627; CY 1116841 T1 20170315; CY 1120709 T1 20191211; DK 2334326 T3 20151019; DK 2946790 T3 20181008; EP 2334326 A2 20110622; EP 2334326 B1 20150729; EP 2946790 A2 20151125; EP 2946790 A3 20160224; EP 2946790 B1 20180704; EP 3388074 A2 20181017; EP 3388074 A3 20181205; EP 3388074 B1 20230823; ES 2550781 T3 20151112; ES 2688118 T3 20181031; ES 2962346 T3 20240318; HK 1214769 A1 20160805; HK 1245136 A1 20180824; HR P20151148 T1 20151218; HR P20181512 T1 20181214; HU E025963 T2 20160530; HU E039860 T2 20190228; JP 2011512363 A 20110421; JP 2014177483 A 20140925; JP 2016216482 A 20161222; JP 2018154650 A 20181004; JP 5804707 B2 20151104; JP 6410764 B2 20181024; KR 101627763 B1 20160607; KR 20100123705 A 20101124; LT 2946790 T 20181025; PL 2334326 T3 20160331; PL 2946790 T3 20190131; PT 2334326 E 20151207; PT 2946790 T 20181102; SI 2334326 T1 20151231; SI 2946790 T1 20181130; US 10517935 B2 20191231; US 11534484 B2 20221227; US 2011092434 A1 20110421; US 2017158744 A1 20170608; US 2020254076 A1 20200813; US 2023201320 A1 20230629; US 9724399 B2 20170808
DOCDB simple family (application)
AT 2009000071 W 20090223; AT 2972008 A 20080222; AU 2009217216 A 20090223; BR PI0908097 A 20090223; CA 2716007 A 20090223; CN 200980105866 A 20090223; CN 201510561387 A 20090223; CN 201710228381 A 20090223; CN 202211233768 A 20090223; CY 151100940 T 20151021; CY 181101007 T 20180928; DK 09712380 T 20090223; DK 15173612 T 20090223; EP 09712380 A 20090223; EP 15173612 A 20090223; EP 18173825 A 20090223; ES 09712380 T 20090223; ES 15173612 T 20090223; ES 18173825 T 20090223; HK 16102825 A 20160311; HK 18104829 A 20180413; HR P20151148 T 20151029; HR P20181512 T 20180924; HU E09712380 A 20090223; HU E15173612 A 20090223; JP 2010547001 A 20090223; JP 2014107332 A 20140523; JP 2016135134 A 20160707; JP 2018111725 A 20180612; KR 20107019372 A 20090223; LT 15173612 T 20090223; PL 09712380 T 20090223; PL 15173612 T 20090223; PT 09712380 T 20090223; PT 15173612 T 20090223; SI 200931295 T 20090223; SI 200931880 T 20090223; US 201615375234 A 20161212; US 201916709999 A 20191211; US 202218057273 A 20221121; US 91807709 A 20090223