Global Patent Index - EP 2953964 A4

EP 2953964 A4 20160914 - METHODS FOR REDUCING AGGREGATE LEVELS IN PROTEIN PREPARATIONS BY TREATMENT WITH THIO-HETEROCYCLIC CATIONS

Title (en)

METHODS FOR REDUCING AGGREGATE LEVELS IN PROTEIN PREPARATIONS BY TREATMENT WITH THIO-HETEROCYCLIC CATIONS

Title (de)

VERFAHREN ZUR REDUZIERUNG VON AGGREGATEBENEN IN PROTEINPRÄPARATEN DURCH BEHANDLUNG MIT THIO-HETEROCYCLISCHEN KATIONEN

Title (fr)

PROCÉDÉS POUR RÉDUIRE LES NIVEAUX D'AGRÉGATS DANS LES PRÉPARATIONS PROTÉINIQUES PAR TRAITEMENT PAR DES CATIONS THIOHÉTÉROCYCLIQUES

Publication

EP 2953964 A4 20160914 (EN)

Application

EP 14749160 A 20140205

Priority

  • US 201361761646 P 20130206
  • SG 2014000048 W 20140205

Abstract (en)

[origin: WO2014123484A1] A method of reducing aggregate and product-contaminant complex content in a protein preparation including a desired protein includes (i) contacting the protein preparation with at least one solid surface comprising at least one surface-bound ligand capable of binding a metal, the surface-bound ligand being capable of binding a metal is initially substantially devoid of a metal, the operating conditions are selected to substantially prevent the binding of the desired protein to the at least one solid surface and (ii) separating the protein preparation from the surface-bound ligand, such that when more than one surface- bound ligand is present, each surface-bound ligand is independently either of the same net charge or charge neutral.

IPC 8 full level

C07K 1/22 (2006.01); B01D 15/36 (2006.01); C07D 279/18 (2006.01); C07K 16/00 (2006.01)

CPC (source: EP US)

A61P 31/12 (2017.12 - EP); B01D 15/34 (2013.01 - US); B01D 15/363 (2013.01 - EP US); C07K 1/14 (2013.01 - US); C07K 1/165 (2013.01 - EP US); C07K 1/20 (2013.01 - US); C07K 16/00 (2013.01 - US); C07K 16/3015 (2013.01 - US); B01D 15/327 (2013.01 - EP US); B01D 15/3828 (2013.01 - EP US)

Citation (search report)

  • [XP] WO 2013180650 A1 20131205 - AGENCY SCIENCE TECH & RES [SG]
  • [Y] VAN BEBBER F ET AL: "Methylene blue fails to inhibit Tau and polyglutamine protein dependent toxicity in zebrafish", NEUROBIOLOGY OF DISEASE, BLACKWELL SCIENTIFIC PUBLICATIONS, OXFORD, GB, vol. 39, no. 3, 1 September 2010 (2010-09-01), pages 265 - 271, XP027169138, ISSN: 0969-9961, [retrieved on 20100408]
  • [Y] SHENG-TAO YANG ET AL: "Removal of methylene blue from aqueous solution by graphene oxide", JOURNAL OF COLLOID AND INTERFACE SCIENCE, ACADEMIC PRESS, NEW YORK, NY, US, vol. 359, no. 1, 27 February 2011 (2011-02-27), pages 24 - 29, XP028200974, ISSN: 0021-9797, [retrieved on 20110306], DOI: 10.1016/J.JCIS.2011.02.064
  • [ADP] GAN HUI THENG ET AL: "Characterization and removal of aggregates formed by nonspecific interaction of IgM monoclonal antibodies with chromatin catabolites during cell culture production", JOURNAL OF CHROMATOGRAPHY, ELSEVIER SCIENCE PUBLISHERS B.V, NL, vol. 1291, 28 March 2013 (2013-03-28), pages 33 - 40, XP028588665, ISSN: 0021-9673, DOI: 10.1016/J.CHROMA.2013.03.028
  • See references of WO 2014123486A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2014123484 A1 20140814; CN 105026417 A 20151104; CN 105051055 A 20151111; EP 2953962 A1 20151216; EP 2953962 A4 20161019; EP 2953964 A1 20151216; EP 2953964 A4 20160914; JP 2016506952 A 20160307; JP 2016508499 A 20160322; JP 6363621 B2 20180725; JP 6410734 B2 20181024; KR 20150113027 A 20151007; KR 20150115745 A 20151014; SG 10201706205R A 20170830; SG 11201505195T A 20150828; SG 11201505460W A 20150828; US 2015368354 A1 20151224; US 2015376230 A1 20151231; US 9975919 B2 20180522; US 9988418 B2 20180605; WO 2014123486 A1 20140814

DOCDB simple family (application)

SG 2014000046 W 20140205; CN 201480007315 A 20140205; CN 201480007804 A 20140205; EP 14748942 A 20140205; EP 14749160 A 20140205; JP 2015555967 A 20140205; JP 2015555969 A 20140205; KR 20157020166 A 20140205; KR 20157022485 A 20140205; SG 10201706205R A 20140205; SG 11201505195T A 20140205; SG 11201505460W A 20140205; SG 2014000048 W 20140205; US 201414766123 A 20140205; US 201414766129 A 20140205