EP 2957567 B1 20190605 - NUCLEOSIDE AND NUCLEOTIDE, HAVING NITROGEN-CONTAINING HETERCYCLE STRUCTURE
Title (en)
NUCLEOSIDE AND NUCLEOTIDE, HAVING NITROGEN-CONTAINING HETERCYCLE STRUCTURE
Title (de)
NUKLEOSID UND NUKLEOTID MIT EINER STICKSTOFFHALTIGEN HETEROCYCLISCHEN STRUKTUR
Title (fr)
NUCLÉOSIDE ET NUCLÉOTIDE POSSÉDANT UNE STRUCTURE HÉTÉROCYCLIQUE AZOTÉE
Publication
Application
Priority
- JP 2013028923 A 20130218
- JP 2014053580 W 20140217
Abstract (en)
[origin: EP2957567A1] The present invention provides compounds shown by the formula: wherein Y 1 is CR 6 or N, Y 2 is CR 7 or N, Y 3 is CR 8 or N, R 6 , R 7 and R 8 are each independently, a hydrogen atom, halogen, cyano, substituted or unsubstituted alkyl or the like, Bx is a nucleic acid base moiety, Z 1 and Z 2 are each independently, a hydrogen atom, a hydroxyl protecting group or a reactive phosphorus group, R 1 to R 5 are each independently, a hydrogen atom, halogen, cyano, substituted or unsubstituted alkyl or the like, and n is an integer of 0 to 3, or salts thereof, that are novel nucleosides or nucleotides that can be useful as materials for synthesizing nucleic acid pharmaceuticals.
IPC 8 full level
C07H 19/06 (2006.01); C07H 19/16 (2006.01); C07H 21/00 (2006.01)
CPC (source: EP US)
A61P 43/00 (2017.12 - EP); C07H 19/06 (2013.01 - EP US); C07H 19/10 (2013.01 - US); C07H 19/16 (2013.01 - EP US); C07H 21/00 (2013.01 - EP US); Y02P 20/55 (2015.11 - EP US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
EP 2957567 A1 20151223; EP 2957567 A4 20160824; EP 2957567 B1 20190605; JP 6292631 B2 20180314; JP WO2014126229 A1 20170202; US 2015368287 A1 20151224; US 9315535 B2 20160419; WO 2014126229 A1 20140821
DOCDB simple family (application)
EP 14751080 A 20140217; JP 2014053580 W 20140217; JP 2015500324 A 20140217; US 201414766827 A 20140217