EP 2959292 B1 20200930 - METHODS FOR ASSESSING LUNG GRAFTS
Title (en)
METHODS FOR ASSESSING LUNG GRAFTS
Title (de)
VERFAHREN ZUR BEURTEILUNG VON LUNGENTRANSPLANTATEN
Title (fr)
PROCÉDÉS POUR L'ÉVALUATION DE GREFFONS DE POUMON
Publication
Application
Priority
- US 201361766862 P 20130220
- CA 2014000138 W 20140220
Abstract (en)
[origin: WO2014127462A1] A method of classifying a lung graft subjected to normothermic ex vivo lung perfusion (EVLP), during perfusion and/or after perfusion, the method comprising: a) collecting a test sample from the lung graft; b) measuring a polypeptide level of a negative transplant predictor gene product selected from CCG predictor gene products M-CSF, IL-8 SCGF-beta, GRO-alpha, G-CSF, MIP-1 alpha, and/or MIP-1beta, endothelin predictor gene products endothelin 1 (ET-1) and/or big ET-1, and/or apoptosis predictor gene products cytokeratin 18 (CK-18), caspase 3 and/or HMGB-1 in the sample and/or determining a metabolite profile of the sample for lung grafts that are from donors where the death was due to cardiac death (DCD); c) identifying the graft as a good candidate for transplant or a poor candidate for transplant wherein an increased polypeptide level of one or more negative transplant outcome predictor gene products compared to an outcome control or a reference metabolic profile is indicative the graft is a poor candidate for transplant.
IPC 8 full level
G01N 33/68 (2006.01); G16C 20/60 (2019.01)
CPC (source: EP US)
G01N 33/68 (2013.01 - EP US); G01N 33/6884 (2013.01 - EP US); G16B 35/00 (2019.01 - EP US); G16C 20/60 (2019.01 - EP US); G01N 2333/5421 (2013.01 - EP); G01N 2333/5754 (2013.01 - US); G01N 2800/245 (2013.01 - EP US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2014127462 A1 20140828; CA 2935866 A1 20140828; CA 2935866 C 20240109; CA 3225539 A1 20140828; EP 2959292 A1 20151230; EP 2959292 A4 20161214; EP 2959292 B1 20200930; EP 3809139 A1 20210421; ES 2831400 T3 20210608; US 2015377904 A1 20151231; US 9835630 B2 20171205
DOCDB simple family (application)
CA 2014000138 W 20140220; CA 2935866 A 20140220; CA 3225539 A 20140220; EP 14754767 A 20140220; EP 20198785 A 20140220; ES 14754767 T 20140220; US 201414768948 A 20140220