EP 2961842 A2 20160106 - METHOD FOR THE TARGETED KILLING OF CELLS BY NUCLEOTIDE MOLECULES DIRECTED FOR MRNA BINDING, AND ALSO NUCLEOTIDE MOLECULES AND APPLICATION KIT FOR SUCH A USE
Title (en)
METHOD FOR THE TARGETED KILLING OF CELLS BY NUCLEOTIDE MOLECULES DIRECTED FOR MRNA BINDING, AND ALSO NUCLEOTIDE MOLECULES AND APPLICATION KIT FOR SUCH A USE
Title (de)
VERFAHREN ZUR GEZIELTEN ABTÖTUNG VON ZELLEN DURCH ZUR MRNA-ANBINDUNG AUSGERICHTETE NUKLEOTID-MOLEKÜLE SOWIE NUKLEOTID-MOLEKÜLE UND APPLIKATIONSKIT FÜR SOLCHE VERWENDUNG
Title (fr)
PROCÉDÉ PERMETTANT DE TUER DE MANIÈRE CIBLÉE DES CELLULES PAR L'INTERMÉDIAIRE DE MOLÉCULES NUCLÉOTIDES ORIENTÉES VERS LA LIAISON À L'ARNM, MOLÉCULES NUCLÉOTIDES ET KIT D'APPLICATION POUR UNE TELLE UTILISATION
Publication
Application
Priority
- DE 102013003869 A 20130227
- EP 2014053666 W 20140226
Abstract (en)
[origin: WO2014131773A2] The object was to kill cells, even in the case of genome mutations, in a broad field of application, efficiently, reliably and as effectively as possible in the organism, without the occurrence of disadvantages and side effects of chemical, physical, biochemical, but in particular molecular-biological, methods that are known per se. According to the invention, for the targeted killing of cells, nucleotide molecules are used which bind by a nucleotide sequence to a single region of the mRNA, which, on the basis of sequencing analyses, is subjected very rarely to a mutation, and therefore, even in the case of increased mutation rates in the entire genome, reliably kill the cell without a required further mRNA binding or other cell activity.
IPC 8 full level
C12N 15/11 (2006.01); A61K 31/7088 (2006.01); C12N 15/113 (2010.01)
CPC (source: EP US)
A61J 1/06 (2013.01 - US); A61K 31/713 (2013.01 - EP US); A61K 45/06 (2013.01 - US); A61M 5/178 (2013.01 - US); C12N 15/111 (2013.01 - EP US); C12N 15/113 (2013.01 - EP US); C12N 15/1137 (2013.01 - US); C12N 2310/14 (2013.01 - EP US); C12N 2320/31 (2013.01 - US)
Citation (search report)
See references of WO 2014131773A2
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
DE 102013003869 A1 20140828; DE 102013003869 B4 20161124; EP 2961842 A2 20160106; US 2016145623 A1 20160526; WO 2014131773 A2 20140904; WO 2014131773 A3 20141023
DOCDB simple family (application)
DE 102013003869 A 20130227; EP 14711693 A 20140226; EP 2014053666 W 20140226; US 201414770877 A 20140226