EP 2962699 A3 20160406 - IMPROVED METHOD FOR PREPARING CONJUGATES OF PROTEINS AND CHELATING AGENTS
Title (en)
IMPROVED METHOD FOR PREPARING CONJUGATES OF PROTEINS AND CHELATING AGENTS
Title (de)
VERBESSERTES VERFAHREN ZUR HERSTELLUNG VON KONJUGATEN VON PROTEINEN UND CHELATBILDNERN
Title (fr)
PROCEDE AMELIORE DE PREPARATION DE CONJUGUES DE PROTEINES ET D'AGENTS DE CHELATION
Publication
Application
Priority
- US 52604403 P 20031201
- EP 04821464 A 20041201
Abstract (en)
[origin: WO2005084179A2] Improved synthesis methods are provided for preparing conjugates of proteins and chelating agents. In the synthesis methods, non-stable bonds are hydrolyzed after the conjugate is synthesized, for example by treating the conjugate with a quenching agent. The synthesis method provides conjugates that are substantially free of non-stable bonds between the protein and the chelating agent, such that the chelating agent is less likely to dissociate with the conjugate after the conjugate has been stored for extended periods. The conjugate may be useful for therapeutic or diagnostic methods.
IPC 8 full level
A61K 51/00 (2006.01); A61K 51/08 (2006.01); A61K 51/10 (2006.01); C07K 14/52 (2006.01); C07K 14/525 (2006.01); C07K 14/54 (2006.01); C07K 16/46 (2006.01)
CPC (source: EP US)
A61K 51/1027 (2013.01 - EP US); A61K 51/1045 (2013.01 - EP US); A61K 51/0482 (2013.01 - EP US)
Citation (search report)
- [X] GARY L GRIFFITHS ET AL: "90Y-DOTA-hLL2: An Agent for Radioimmunotherapy of Non-Hodgkin's Lymphoma", THE JOURNAL OF NUCLEAR MEDICINE, vol. 44, no. 1, 1 January 2003 (2003-01-01), US, pages 77, XP055226570, ISSN: 0161-5505
- [XD] GOVINDAN S V ET AL: "90YTTRIUM-LABELED COMPLEMENTARITY-DETERMINING-REGION-GRAFTED MONOCLONAL ANTIBODIES FOR RADIOIMMUNOTHERAPY: RADIOLABELING AND ANIMAL BIODISTRIBUTION STUDIES", BIOCONJUGATE CHEMISTRY, ACS, WASHINGTON, DC, US, vol. 9, no. 6, 1 November 1998 (1998-11-01), pages 773 - 782, XP000982306, ISSN: 1043-1802, DOI: 10.1021/BC980040G
Designated contracting state (EPC)
DE FR GB IT NL
DOCDB simple family (publication)
WO 2005084179 A2 20050915; WO 2005084179 A3 20060316; EP 1689448 A2 20060816; EP 1689448 A4 20101013; EP 1689448 B1 20150729; EP 2962699 A2 20160106; EP 2962699 A3 20160406; JP 2007535492 A 20071206; JP 4912153 B2 20120411; US 2005191239 A1 20050901; US 7259249 B2 20070821
DOCDB simple family (application)
US 2004040046 W 20041201; EP 04821464 A 20041201; EP 15002212 A 20041201; JP 2006542675 A 20041201; US 50004 A 20041201