EP 2963043 B1 20180530 - TETRAHYDROIMIDAZO[1,5-D][1,4]OXAZEPINE DERIVATIVE
Title (en)
TETRAHYDROIMIDAZO[1,5-D][1,4]OXAZEPINE DERIVATIVE
Title (de)
TETRAHYDROIMIDAZO[1,5-D][1,4]OXAZEPINDERIVAT
Title (fr)
DÉRIVÉ DE TÉTRAHYDROIMIDAZO[1,5-D][1,4]OXAZÉPINE
Publication
Application
Priority
- US 201361770469 P 20130228
- JP 2014054724 W 20140226
Abstract (en)
[origin: US2014243316A1] A compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof works as an mGluR2 antagonist, and is applicable as a therapeutic agent for neurological disorders related to glutamate dysfunction and diseases involving the mGluR2, such as Alzheimer's disease: wherein R is a hydrogen atom, a C1-6 alkyl group or the like, R1 is a C1-6 alkyl group, a C1-6 alkoxy group or the like, R2 is a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group or the like, R3 is a hydrogen atom, a C1-6 alkyl group or the like, and R4 is a C1-6 alkyl group or the like.
IPC 8 full level
C07D 498/04 (2006.01); A61K 31/553 (2006.01); A61P 25/28 (2006.01)
CPC (source: CN EP RU US)
A61K 31/553 (2013.01 - RU); A61P 25/00 (2017.12 - EP); A61P 25/28 (2017.12 - EP); C07D 498/04 (2013.01 - CN EP RU US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
US 2014243316 A1 20140828; US 9458176 B2 20161004; AR 094887 A1 20150902; AU 2014221775 A1 20150723; AU 2014221775 B2 20170824; BR 112015020545 A2 20170718; CA 2901168 A1 20140904; CA 2901168 C 20200922; CL 2015002391 A1 20160205; CN 105008375 A 20151028; CN 105008375 B 20161228; CY 1121231 T1 20200529; DK 2963043 T3 20180903; EP 2963043 A1 20160106; EP 2963043 A4 20160720; EP 2963043 B1 20180530; ES 2685025 T3 20181005; HK 1217697 A1 20170120; HR P20181349 T1 20181019; HU E040219 T2 20190228; IL 240402 A0 20150924; IL 240402 A 20170928; JP 5654715 B1 20150114; JP WO2014133022 A1 20170202; KR 102190597 B1 20201215; KR 20150120381 A 20151027; LT 2963043 T 20181010; MX 2015010741 A 20160108; MX 362920 B 20190226; PE 20151651 A1 20151107; PH 12015501878 A1 20151207; PL 2963043 T3 20181031; PT 2963043 T 20181009; RS 57602 B1 20181130; RU 2015135967 A 20170403; RU 2659219 C2 20180629; SG 11201505252V A 20150828; SI 2963043 T1 20180928; TW 201443062 A 20141116; TW I622592 B 20180501; UA 114950 C2 20170828; WO 2014133022 A1 20140904
DOCDB simple family (application)
US 201414190356 A 20140226; AR P140100595 A 20140226; AU 2014221775 A 20140226; BR 112015020545 A 20140226; CA 2901168 A 20140226; CL 2015002391 A 20150826; CN 201480009750 A 20140226; CY 181100881 T 20180823; DK 14756740 T 20140226; EP 14756740 A 20140226; ES 14756740 T 20140226; HK 16105614 A 20160516; HR P20181349 T 20180823; HU E14756740 A 20140226; IL 24040215 A 20150806; JP 2014054724 W 20140226; JP 2014541469 A 20140226; KR 20157022943 A 20140226; LT 14756740 T 20140226; MX 2015010741 A 20140226; PE 2015001791 A 20140226; PH 12015501878 A 20150826; PL 14756740 T 20140226; PT 14756740 T 20140226; RS P20180992 A 20140226; RU 2015135967 A 20140226; SG 11201505252V A 20140226; SI 201430830 T 20140226; TW 103106584 A 20140226; UA A201508269 A 20140226