Global Patent Index - EP 2967017 A4

EP 2967017 A4 20161109 - TRANSGENIC ANIMALS WITH CUSTOMIZABLE TRAITS

Title (en)

TRANSGENIC ANIMALS WITH CUSTOMIZABLE TRAITS

Title (de)

TRANSGENE TIERE MIT ANPASSBAREN MERKMALEN

Title (fr)

ANIMAUX TRANSGÉNIQUES AYANT DES CARACTÉRISTIQUES PERSONNALISABLES

Publication

EP 2967017 A4 20161109 (EN)

Application

EP 14763711 A 20140315

Priority

  • US 201313837405 A 20130315
  • US 2014029918 W 20140315

Abstract (en)

[origin: WO2014145196A2] Disclosed are materials and methods for creating customizable traits in animals. In the demonstration of the principle of the subject invention, a keratin-14 specific promoter is used with red fluorescent protein in the loxp cassette, dominant black (ΔG23) beta defensin 103 in the pigment cassette, and an SV40 (with intron) polyadenylation sequence. When Cre recombinase (or HTNCre) is applied to the animal's skin in a carrier base (e.g., lipid bilayers), fur is permanently genetically modified to tum black in the shape in which theHTNCre was applied.

IPC 8 full level

A01K 67/027 (2006.01); C12N 5/07 (2010.01); C12N 15/09 (2006.01); C12N 15/85 (2006.01)

CPC (source: EP)

A01K 67/0275 (2013.01); C12N 15/8509 (2013.01); A01K 2227/101 (2013.01); A01K 2267/02 (2013.01)

Citation (search report)

  • [XP] WO 2013123365 A1 20130822 - MICE WITH HORNS LLC [US]
  • [X] WO 02086098 A2 20021031 - UNIV VIRGINIA [US], et al
  • [X] C. A. CRONIN ET AL: "The lac operator-repressor system is functional in the mouse", GENES & DEVELOPMENT, vol. 15, no. 12, 15 June 2001 (2001-06-15), pages 1506 - 1517, XP055305339, DOI: 10.1101/gad.892001
  • [X] C. DONG ET AL: "Coat color determination by miR-137 mediated down-regulation of microphthalmia-associated transcription factor in a mouse model", RNA, vol. 18, no. 9, 30 July 2012 (2012-07-30), US, pages 1679 - 1686, XP055282537, ISSN: 1355-8382, DOI: 10.1261/rna.033977.112
  • [Y] SHEILA M. SCHMUTZ ET AL: "Interaction of MC1R and PMEL alleles on solid coat colors in Highland cattle", ANIMAL GENETICS., vol. 44, no. 1, 24 February 2013 (2013-02-24), GB, pages 9 - 13, XP055304916, ISSN: 0268-9146, DOI: 10.1111/j.1365-2052.2012.02361.x
  • [Y] WILFRIED A KUES ET AL: "Advances in farm animal transgenesis", PREVENTIVE VETERINARY MEDICINE, vol. 102, no. 2, 1 November 2011 (2011-11-01), pages 146 - 156, XP028311241, ISSN: 0167-5877, [retrieved on 20110418], DOI: 10.1016/J.PREVETMED.2011.04.009
  • [A] K. BEHRENDT ET AL: "A function for Rac1 in the terminal differentiation and pigmentation of hair", JOURNAL OF CELL SCIENCE, vol. 125, no. 4, 15 February 2012 (2012-02-15), pages 896 - 905, XP055082266, ISSN: 0021-9533, DOI: 10.1242/jcs.091868
  • [AP] BRENDA WATT ET AL: "PMEL: a pigment cell-specific model for functional amyloid formation", PIGMENT CELL & MELANOMA RESEARCH, vol. 26, no. 3, 19 May 2013 (2013-05-19), United States, Denmark, pages 300 - 315, XP055304913, ISSN: 1755-1471, DOI: 10.1111/pcmr.12067
  • [A] SASAKI ET AL: "A system for conditional RNA interference in the mouse using the lac operator - repressor system", ABSTRACTS OF THE ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE, OCIETY FOR NEUROSCIENCE, vol. 2003, no. ABSTRACT NO. 325.4, 8 November 2003 (2003-11-08), XP002979518, ISSN: 0190-5295
  • [A] LIANG CHIH-CHIA ET AL: "Transgenic mice exhibiting inducible and spontaneous Cre activities driven by a bovine keratin 5 promoter that can be used for the conditional analysis of basal epithelial cells in multiple organs", JOURNAL OF BIOMEDICAL SCIENCE, KLUWER ACADEMIC PUBLISHERS, DO, vol. 16, no. 1, 8 January 2009 (2009-01-08), pages 2, XP021047134, ISSN: 1423-0127, DOI: 10.1186/1423-0127-16-2
  • [A] CANDILLE S I ET AL: "A â-Defensin Mutation Causes Black Coat Color in Domestic Dogs", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 318, no. 5855, 30 November 2007 (2007-11-30), pages 1418 - 1423, XP002610513, ISSN: 1095-9203, [retrieved on 20071018], DOI: 10.1126/SCIENCE.1147880
  • See references of WO 2014145196A2

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2014145196 A2 20140918; WO 2014145196 A3 20150219; AU 2014233317 A1 20151029; AU 2014233317 B2 20170831; AU 2017213487 A1 20170831; AU 2017213487 B2 20190704; AU 2019204084 A1 20190704; BR 112015023414 A2 20171128; CA 2906936 A1 20140918; CN 105357960 A 20160224; CN 105357960 B 20180216; EP 2967017 A2 20160120; EP 2967017 A4 20161109; HK 1214732 A1 20160805; JP 2016512697 A 20160509; MX 2015013253 A 20160407

DOCDB simple family (application)

US 2014029918 W 20140315; AU 2014233317 A 20140315; AU 2017213487 A 20170809; AU 2019204084 A 20190611; BR 112015023414 A 20140315; CA 2906936 A 20140315; CN 201480024934 A 20140315; EP 14763711 A 20140315; HK 16102648 A 20160308; JP 2016503281 A 20140315; MX 2015013253 A 20140315