Global Patent Index - EP 2968394 A4

EP 2968394 A4 20160420 - NOVEL VACCINES AGAINST MULTIPLE SUBTYPES OF DENGUE VIRUS

Title (en)

NOVEL VACCINES AGAINST MULTIPLE SUBTYPES OF DENGUE VIRUS

Title (de)

NEUARTIGE IMPFSTOFFE GEGEN MEHRERE SUBTYPEN DES DENGUE-VIRUS

Title (fr)

NOUVEAUX VACCINS CONTRE DE MULTIPLES SOUS-TYPES DU VIRUS DE LA DENGUE

Publication

EP 2968394 A4 20160420 (EN)

Application

EP 14763126 A 20140314

Priority

  • US 201361801972 P 20130315
  • US 2014029341 W 20140314

Abstract (en)

[origin: CN105246491A] An aspect of the present invention is related to nucleic acid constructs capable of expressing a polypeptide, such as a consensus dengue prME that elicits an immune response in a mammal against more than one subtype of dengue virus, and methods of use thereof. Additionally, there are DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of dengue virus subtypes, comprising a DNA plasmid and a pharmaceutically acceptable excipient, and methods of use thereof. The DNA plasmid is capable of expressing a consensus dengue antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal that is cross reactive against all 4 dengue subtypes.

IPC 8 full level

A61K 31/711 (2006.01); A61K 39/12 (2006.01); A61K 39/295 (2006.01)

CPC (source: EP)

A61K 31/7088 (2013.01); A61K 39/12 (2013.01); A61K 39/295 (2013.01); A61K 2039/53 (2013.01); A61K 2039/545 (2013.01); Y02A 50/30 (2017.12)

Citation (search report)

  • [X] WO 2009073330 A2 20090611 - UNIV PENNSYLVANIA [US], et al
  • [XI] APT D ET AL: "Tetravalent neutralizing antibody response against four dengue serotypes by a single chimeric dengue envelope antigen", VACCINE, ELSEVIER LTD, GB, vol. 24, no. 3, 16 January 2006 (2006-01-16), pages 335 - 344, XP028010449, ISSN: 0264-410X, [retrieved on 20060116], DOI: 10.1016/J.VACCINE.2005.07.100
  • [XI] RAVIPRAKASH K ET AL: "A chimeric tetravalent dengue DNA vaccine elicits neutralizing antibody to all four virus serotypes in rhesus macaques", VIROLOGY, ELSEVIER, AMSTERDAM, NL, vol. 353, no. 1, 15 September 2006 (2006-09-15), pages 166 - 173, XP024896386, ISSN: 0042-6822, [retrieved on 20060915], DOI: 10.1016/J.VIROL.2006.05.005
  • [XI] RAMANATHAN M P ET AL: "Development of a novel DNA SynCon(TM) tetravalent dengue vaccine that elicits immune responses against four serotypes", VACCINE, ELSEVIER LTD, GB, vol. 27, no. 46, 30 October 2009 (2009-10-30), pages 6444 - 6453, XP026704481, ISSN: 0264-410X, [retrieved on 20090704], DOI: 10.1016/J.VACCINE.2009.06.061
  • [X] RAMANATHAN M P ET AL: "Coimmunization with an optimized IL15 plasmid adjuvant enhances humoral immunity via stimulating B cells induced by genetically engineered DNA vaccines expressing consensus JEV and WNV E DIII", VACCINE, ELSEVIER LTD, GB, vol. 27, no. 32, 9 July 2009 (2009-07-09), pages 4370 - 4380, XP026210587, ISSN: 0264-410X, [retrieved on 20090306], DOI: 10.1016/J.VACCINE.2009.01.137
  • [X] DOMINICK J LADDY ET AL: "Heterosubtypic protection against pathogenic human and avian influenza viruses via in vivo electroporation of synthetic consensus DNA antigens", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, US, vol. 3, no. 6, 1 June 2008 (2008-06-01) - 1 June 2008 (2008-06-01), pages 1 - 8, XP008132555, ISSN: 1932-6203, DOI: 10.1371/JOURNAL.PONE.0002517
  • [T] LADDY ET AL: "Immunogenicity of novel consensus-based DNA vaccines against avian influenza", VACCINE, ELSEVIER LTD, GB, vol. 25, no. 16, 29 March 2007 (2007-03-29), pages 2984 - 2989, XP022004278, ISSN: 0264-410X, DOI: 10.1016/J.VACCINE.2007.01.063
  • [T] NIRANJAN Y SARDESAI ET AL: "Electroporation delivery of DNA vaccines: prospects for success", CURRENT OPINION IN IMMUNOLOGY, vol. 23, no. 3, 1 June 2008 (2008-06-01), pages 421 - 429, XP028223967, ISSN: 0952-7915, [retrieved on 20110330], DOI: 10.1016/J.COI.2011.03.008
  • See references of WO 2014144786A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

DOCDB simple family (publication)

CN 105246491 A 20160113; CN 105246491 B 20190419; CN 110055265 A 20190726; EP 2968394 A1 20160120; EP 2968394 A4 20160420; HK 1219904 A1 20170421; JP 2016515816 A 20160602; JP 6457481 B2 20190123; KR 20160004267 A 20160112; MX 2015011485 A 20160923; MX 365656 B 20190610

DOCDB simple family (application)

CN 201480013820 A 20140314; CN 201910229555 A 20140314; EP 14763126 A 20140314; HK 16108101 A 20160711; JP 2016503065 A 20140314; KR 20157028919 A 20140314; MX 2015011485 A 20140314