EP 2968609 A4 20161130 - VECTORS AND METHODS TO TREAT ISCHEMIA
Title (en)
VECTORS AND METHODS TO TREAT ISCHEMIA
Title (de)
VEKTOREN UND VERFAHREN ZUR BEHANDLUNG VON ISCHÄMIE
Title (fr)
VECTEURS ET MÉTHODES POUR TRAITER L'ISCHÉMIE
Publication
Application
Priority
- US 201313844138 A 20130315
- US 2013057721 W 20130830
- US 2014029386 W 20140314
Abstract (en)
[origin: WO2014144815A2] This disclosure relates to vectors, isolated cells, compositions, and methods for the treatment of critical limb ischemia and associated disorders. One aspect of the disclosure relates to a vector comprising a nucleic acid encoding a 165A isoform VEGF protein and a promoter that regulates expression of the nucleic acid encoding the VEGF.
IPC 8 full level
C12N 15/867 (2006.01); A61K 48/00 (2006.01)
CPC (source: EP)
A61K 35/545 (2013.01); A61K 38/18 (2013.01); A61K 38/1866 (2013.01); A61K 38/1891 (2013.01); C07K 14/52 (2013.01); C12N 15/86 (2013.01); C12N 2740/16043 (2013.01)
Citation (search report)
- [XI] DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; September 1996 (1996-09-01), ZHOU A ET AL: "[Molecular bypass, the application of VEGF to gene therapy of limb ischemia].", XP002762757, Database accession no. NLM9275547
- [I] FIERRO FERNANDO A ET AL: "Effects on Proliferation and Differentiation of Multipotent Bone Marrow Stromal Cells Engineered to Express Growth Factors for Combined Cell and Gene Therapy", STEM CELLS (MIAMISBURG), vol. 29, no. 11, November 2011 (2011-11-01), pages 1727 - 1737, XP002717241
- [I] CHANG DAVID S ET AL: "Adeno-associated viral vector-mediated gene transfer of VEGF normalizes skeletal muscle oxygen tension and induces arteriogenesis in ischemic rat hindlimb.", MOLECULAR THERAPY : THE JOURNAL OF THE AMERICAN SOCIETY OF GENE THERAPY, vol. 7, no. 1, January 2003 (2003-01-01), pages 44 - 51, XP002717242, ISSN: 1525-0016
- [A] AFRAMIAN D J ET AL: "Using HSV-thymidine kinase for safety in an allogeneic salivary graft cell line", TISSUE ENGINEERING, vol. 7, no. 4, 1 August 2001 (2001-08-01), LARCHMONT, NY, US, pages 405 - 413, XP002761134, ISSN: 1076-3279
- [I] DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; May 2010 (2010-05-01), FANG YU XIANG ET AL: "Development of Chimeric Gene Regulators for Cancer-specific Gene Therapy with both Transcriptional and Translational Targeting", XP002762768, Database accession no. PREV201000282618 & MOLECULAR BIOTECHNOLOGY, vol. 45, no. 1, May 2010 (2010-05-01), pages 71 - 81, ISSN: 1073-6085, DOI: 10.1007/S12033-010-9244-Y
- [A] AKESON ANN L ET AL: "Temporal and spatial regulation of VEGF-A controls vascular patterning in the embryonic lung.", DEVELOPMENTAL BIOLOGY, vol. 264, no. 2, 15 December 2003 (2003-12-15), pages 443 - 455, XP002762759, ISSN: 0012-1606
- [A] NAIDOO JERUSHA ET AL: "Gene regulation systems for gene therapy applications in the central nervous system.", NEUROLOGY RESEARCH INTERNATIONAL, vol. 2012, 595410, 2012, pages 1 - 10, XP002762760, ISSN: 2090-1860, DOI: 10.1155/2012/595410
- See references of WO 2014144815A2
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2014144815 A2 20140918; WO 2014144815 A3 20141106; AU 2014228526 A1 20151105; AU 2019201858 A1 20190411; EP 2968609 A2 20160120; EP 2968609 A4 20161130
DOCDB simple family (application)
US 2014029386 W 20140314; AU 2014228526 A 20140314; AU 2019201858 A 20190318; EP 14765183 A 20140314