EP 2970234 B1 20180718 - METHODS OF SYNTHESIZING A DIFLUOROLACTAM ANALOG
Title (en)
METHODS OF SYNTHESIZING A DIFLUOROLACTAM ANALOG
Title (de)
VERFAHREN ZUR HERSTELLUNG EINES DIFLUOROLACTAM-ANALOGONS
Title (fr)
PROCÉDÉS DE SYNTHÈSE D'UN ANALOGUE DIFLUOROLACTAM
Publication
Application
Priority
- US 201361799334 P 20130315
- US 2014028933 W 20140314
Abstract (en)
[origin: WO2014144500A2] The present invention relates to processes and intermediates for preparing compounds of formula (IA), wherein R1, R4, R5, R6, and L1 are as defined herein. Compounds of formula (IA) have been found useful as EP4 receptor agonists useful in the treatment of glaucoma, osteoporosis, neuropathic pain, and related disorders.
IPC 8 full level
C07C 69/63 (2006.01); C07D 207/273 (2006.01); C07D 333/38 (2006.01); C07D 409/06 (2006.01); C07D 498/04 (2006.01); C07F 9/38 (2006.01); C07F 9/40 (2006.01)
CPC (source: EP IL US)
A61P 19/10 (2017.12 - EP); A61P 25/04 (2017.12 - EP); A61P 27/06 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07B 39/00 (2013.01 - IL); C07D 207/273 (2013.01 - EP US); C07D 333/38 (2013.01 - EP US); C07D 409/06 (2013.01 - EP US); C07D 498/04 (2013.01 - EP IL US); C07F 9/4006 (2013.01 - EP US)
Citation (examination)
WO 0245853 A1 20020613 - DOYLE MICHAEL P [US], et al
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2014144500 A2 20140918; WO 2014144500 A3 20150528; AU 2014229065 A1 20150917; AU 2014229065 B2 20170309; CA 2903314 A1 20140918; CA 2903314 C 20230214; EP 2970234 A2 20160120; EP 2970234 B1 20180718; HK 1215022 A1 20160812; IL 241042 A0 20151130; IL 241042 B 20211031; JP 2016519669 A 20160707; JP 6368351 B2 20180801; US 11345690 B2 20220531; US 2016060253 A1 20160303; US 2018170918 A1 20180621; US 2019202816 A1 20190704; US 2022127252 A9 20220428; US 9914725 B2 20180313
DOCDB simple family (application)
US 2014028933 W 20140314; AU 2014229065 A 20140314; CA 2903314 A 20140314; EP 14723569 A 20140314; HK 16102932 A 20160314; IL 24104215 A 20150902; JP 2016502940 A 20140314; US 201414775591 A 20140314; US 201815883724 A 20180130; US 201916299916 A 20190312