EP 2970437 A1 20160120 - COMMON LIGHT CHAIN MOUSE
Title (en)
COMMON LIGHT CHAIN MOUSE
Title (de)
MAUS MIT GEWÖHNLICHEN LEICHTEN KETTEN
Title (fr)
SOURIS À CHAINE LÉGÈRE CLASSIQUE
Publication
Application
Priority
- US 201313798310 A 20130313
- US 2014025982 W 20140313
Abstract (en)
[origin: WO2014160179A1] A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that express just one or a few immunoglobulin light chain variable domains from a limited repertoire in their germline. Methods for making bispecific antibodies having universal light chains using mice as described herein, including human light chain variable regions, are provided. Methods for making human variable regions suitable for use in multispecific binding proteins, e.g., bispecific antibodies, and host cells are provided. Bispecific antibodies capable of binding first and second antigens are provided, wherein the first and second antigens are separate epitopes of a single protein or separate epitopes on two different proteins are provided.
IPC 8 full level
C07K 16/00 (2006.01); A01K 67/027 (2006.01); C07K 16/46 (2006.01); C12N 15/85 (2006.01)
CPC (source: EP)
A01K 67/0278 (2013.01); C07K 16/00 (2013.01); C07K 16/28 (2013.01); C12N 15/8509 (2013.01); A01K 2207/15 (2013.01); A01K 2217/072 (2013.01); A01K 2217/15 (2013.01); A01K 2227/105 (2013.01); A01K 2267/01 (2013.01); C07K 2317/14 (2013.01); C07K 2317/21 (2013.01); C07K 2317/31 (2013.01); C07K 2317/515 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01)
Citation (search report)
See references of WO 2014160179A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2014160179 A1 20141002; WO 2014160179 A4 20141120; AU 2014244079 A1 20150924; CA 2903696 A1 20141002; CN 105189545 A 20151223; EP 2970437 A1 20160120; HK 1218550 A1 20170224; IL 240562 A0 20150924; JP 2016519568 A 20160707; KR 20150126863 A 20151113; MX 2015012540 A 20160419; NL 2012424 A 20140916; NL 2012424 C2 20141208; NL 2013851 A 20150112; NL 2013851 C2 20150608; NL 2014775 A 20150609; NL 2014775 B1 20160316; NL 2015603 A 20160316; NL 2015603 B1 20160923; RU 2015143108 A 20170420; SG 11201506294T A 20150929
DOCDB simple family (application)
US 2014025982 W 20140313; AU 2014244079 A 20140313; CA 2903696 A 20140313; CN 201480013861 A 20140313; EP 14722432 A 20140313; HK 16106452 A 20160606; IL 24056215 A 20150813; JP 2016502014 A 20140313; KR 20157025655 A 20140313; MX 2015012540 A 20140313; NL 2012424 A 20140313; NL 2013851 A 20141121; NL 2014775 A 20150507; NL 2015603 A 20151012; RU 2015143108 A 20140313; SG 11201506294T A 20140313