EP 2970491 A4 20161123 - MONOCLONAL ANTIBODIES TO EGFR, AND USES THEREFOR
Title (en)
MONOCLONAL ANTIBODIES TO EGFR, AND USES THEREFOR
Title (de)
MONOKLONALE ANTIKÖRPER GEGEN EGFR UND VERWENDUNGEN DAFÜR
Title (fr)
ANTICORPS MONOCLONAUX CONTRE L'EGFR ET LEURS UTILISATIONS
Publication
Application
Priority
- US 201361790698 P 20130315
- US 2014026171 W 20140313
Abstract (en)
[origin: US2014271477A1] The present invention relates to isolated monoclonal anti-EGFR antibodies, and to the use of such antibodies and antibody fragments to detect EGFR, particularly those expressed by cancer cells. The antibodies are useful in diagnostic as well as therapeutic indications. Methods, devices and kits for the immunodetection and immunotherapy of cells expressing EGFR is also encompassed.
IPC 8 full level
C07K 16/28 (2006.01)
CPC (source: EP US)
C07K 16/2863 (2013.01 - EP US); G01N 33/566 (2013.01 - EP US); G01N 2333/485 (2013.01 - EP US)
Citation (search report)
- [I] WO 02092771 A2 20021121 - LUDWIG INST CANCER RES [US], et al
- [I] WO 2009023265 A1 20090219 - LUDWIG INST CANCER RES [US], et al
- [I] WO 2012024659 A2 20120223 - MASSACHUSETTS INST TECHNOLOGY [US], et al
- [A] WO 2012058592 A2 20120503 - IMMUNOGEN INC [US], et al
- [A] WO 2010022736 A2 20100304 - SYMPHOGEN AS [DK], et al
- [A] WO 03012072 A2 20030213 - UNIV PENNSYLVANIA [US], et al
- [I] GAN HUI K ET AL: "Targeting a unique EGFR epitope with monoclonal antibody 806 activates NF-kappaB and initiates tumour vascular normalization.", JOURNAL OF CELLULAR AND MOLECULAR MEDICINE SEP 2009, vol. 13, no. 9B, September 2009 (2009-09-01), pages 3993 - 4001, XP002763061, ISSN: 1582-4934
Citation (examination)
- WO 2012162418 A1 20121129 - UNIV NORTH CAROLINA [US], et al
- WO 2011140254 A1 20111110 - ADIMAB LLC [US], et al
- WO 2005079434 A2 20050901 - UNIV NORTH CAROLINA [US], et al
- WO 03012047 A2 20030213 - AGENSYS INC [US]
- LO HUI-WEN ET AL: "Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer.", CANCER RESEARCH 01 JAN 2005, vol. 65, no. 1, 1 January 2005 (2005-01-01), pages 338 - 348, ISSN: 0008-5472
- CELLSIGNAL.CIOM: "PathScan® Phospho-EGF Receptor (Tyr1068) Sandwich ELISA Kit #7240", 20 September 2017 (2017-09-20), Retrieved from the Internet <URL:https://www.cellsignal.com/products/elisa-kits/phospho-egf-receptor-tyr1068-sandwich-elisa-kit/7240> [retrieved on 20170920]
- THERMO SCIENTIFIC: "Epidermal Growth Factor Receptor (EGFR) Ab-11 (Clone 199.12)", 11 June 2007 (2007-06-11), Retrieved from the Internet <URL:http://www.immunologic.nl/afbeeldingen/bestanden/MS-396-XXX.pdf> [retrieved on 20170920]
- MERCK MILLIPORE: "GR01 | Anti-EGFR (Ab-1) Mouse mAb (528)", 25 October 2007 (2007-10-25), Retrieved from the Internet <URL:http://www.merckmillipore.com/NL/en/product/Anti-EGFR-%28Ab-1%29-Mouse-mAb-%28528%29,EMD_BIO-GR01> [retrieved on 20170920]
- THERMO SCIENTIFIC: "EGFR Monoclonal Antibody (528)", 20 September 2017 (2017-09-20), Retrieved from the Internet <URL:https://www.thermofisher.com/antibody/product/EGFR-Antibody-clone-528-Monoclonal/MA5-12875> [retrieved on 20170920]
- See also references of WO 2014151649A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
US 2014271477 A1 20140918; US 9840560 B2 20171212; EP 2970491 A1 20160120; EP 2970491 A4 20161123; WO 2014151649 A1 20140925
DOCDB simple family (application)
US 201414209976 A 20140313; EP 14767409 A 20140313; US 2014026171 W 20140313