EP 2973135 A1 20160120 - ASSAYS FOR SELECTING A TREATMENT REGIMEN FOR A SUBJECT WITH DEPRESSION AND COMPOSITIONS COMPRISING FOLATE FOR THERAPY
Title (en)
ASSAYS FOR SELECTING A TREATMENT REGIMEN FOR A SUBJECT WITH DEPRESSION AND COMPOSITIONS COMPRISING FOLATE FOR THERAPY
Title (de)
ASSAYS ZUR AUSWAHL EINES BEHANDLUNGSPLANS FÜR EINE PERSON MIT DEPRESSIONEN UND FOLAT ENTHALTENDE ZUSAMMENSETZUNGEN ZUR THERAPIE
Title (fr)
TESTS DE SÉLECTION D'UN RÉGIME DE TRAITEMENT POUR UN SUJET ATTEINT DE DÉPRESSION ET COMPOSITIONS COMPRENANT DE FOLATE POUR LA THÉRAPIE
Publication
Application
Priority
- US 201361777650 P 20130312
- US 201313796362 A 20130312
- US 201361914338 P 20131210
- US 2014023695 W 20140311
Abstract (en)
[origin: WO2014164882A1] The present invention provides assays, methods and compositions for selecting a treatment regimen for a patient having depression or at risk for depression and/or treating at least one symptom of depression in the subject, based on the recognition that specific combinations of single nucleotide polymorphisms (SNPs) are associated with a therapeutic response to a folate-comprising compound. Provided herein are also methods for improving the effectiveness of an antidepressant drug administered to a subject with depression or at risk for depression by administering an adjunctive therapy of a folate-comprising compound to the subject if the subject carries a specific combination of SNPs that are predictive of a therapeutic response. Furthermore, provided herein are compositions of the folate-comprising compound.
IPC 8 full level
C12Q 1/68 (2006.01); G06F 19/22 (2011.01)
CPC (source: EP)
A61P 25/24 (2017.12); C12Q 1/6883 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/156 (2013.01)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2014164882 A1 20141009; AU 2014248949 A1 20150910; BR 112015022820 A2 20170718; BR 112015022820 A8 20191126; CA 2904418 A1 20141009; CN 105518685 A 20160420; EP 2973135 A1 20160120; EP 2973135 A4 20161116; IL 241156 A0 20151130; JP 2016518816 A 20160630; KR 20150131147 A 20151124; MX 2015012520 A 20160112; RU 2015143177 A 20170418; TW 201437635 A 20141001
DOCDB simple family (application)
US 2014023695 W 20140311; AU 2014248949 A 20140311; BR 112015022820 A 20140311; CA 2904418 A 20140311; CN 201480026826 A 20140311; EP 14778792 A 20140311; IL 24115615 A 20150903; JP 2016501318 A 20140311; KR 20157028347 A 20140311; MX 2015012520 A 20140311; RU 2015143177 A 20140311; TW 103108591 A 20140311