EP 2973135 A4 20161116 - ASSAYS AND METHODS FOR SELECTING A TREATMENT REGIMEN FOR A SUBJECT WITH DEPRESSION
Title (en)
ASSAYS AND METHODS FOR SELECTING A TREATMENT REGIMEN FOR A SUBJECT WITH DEPRESSION
Title (de)
ASSAYS UND VERFAHREN ZUR AUSWAHL EINES BEHANDLUNGSPLANS FÜR EINE PERSON MIT DEPRESSIONEN
Title (fr)
TESTS ET PROCÉDÉS DE SÉLECTION D'UN RÉGIME DE TRAITEMENT POUR UN SUJET ATTEINT DE DÉPRESSION
Publication
Application
Priority
- US 201361777650 P 20130312
- US 201313796362 A 20130312
- US 201361914338 P 20131210
- US 2014023695 W 20140311
Abstract (en)
[origin: WO2014164882A1] The present invention provides assays, methods and compositions for selecting a treatment regimen for a patient having depression or at risk for depression and/or treating at least one symptom of depression in the subject, based on the recognition that specific combinations of single nucleotide polymorphisms (SNPs) are associated with a therapeutic response to a folate-comprising compound. Provided herein are also methods for improving the effectiveness of an antidepressant drug administered to a subject with depression or at risk for depression by administering an adjunctive therapy of a folate-comprising compound to the subject if the subject carries a specific combination of SNPs that are predictive of a therapeutic response. Furthermore, provided herein are compositions of the folate-comprising compound.
IPC 8 full level
C12Q 1/68 (2006.01); G06F 19/22 (2011.01)
CPC (source: EP)
A61P 25/24 (2017.12); C12Q 1/6883 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/156 (2013.01)
Citation (search report)
- [YA] WO 2012128799 A2 20120927 - GEN HOSPITAL CORP [US], et al
- [Y] US 2012115147 A1 20120510 - LOMBARD JAY L [US]
- [XP] WO 2013074676 A2 20130523 - GEN HOSPITAL CORP [US], et al
- [YA] JAIN ET AL.: "Personalized Therapy of Adjunctive L-methylfolate to Selective Serotonin Reuptake Inhibitor-Resistant Major Depressive Disorder.'", POSTER PRESENTATION AT THE COLLEGE OF PSYCHIATRIC AND NEUROLOGIC PHARMACISTS ANNUAL MEETING, [ONLINE], 2 May 2012 (2012-05-02), XP055287748, Retrieved from the Internet <URL:http://www.psychiatrictimes.com/all/editorial/psychiatrictimes/pdfs/jainCPNPBiomarker.pdf> [retrieved on 20160712]
- [Y] TARO KISHI ET AL: "GTP cyclohydrolase 1 gene haplotypes as predictors of SSRI response in Japanese patients with major depressive disorder", JOURNAL OF AFFECTIVE DISORDERS., vol. 142, no. 1-3, 1 December 2012 (2012-12-01), NL, pages 315 - 322, XP055307006, ISSN: 0165-0327, DOI: 10.1016/j.jad.2012.05.004
- See references of WO 2014164882A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2014164882 A1 20141009; AU 2014248949 A1 20150910; BR 112015022820 A2 20170718; BR 112015022820 A8 20191126; CA 2904418 A1 20141009; CN 105518685 A 20160420; EP 2973135 A1 20160120; EP 2973135 A4 20161116; IL 241156 A0 20151130; JP 2016518816 A 20160630; KR 20150131147 A 20151124; MX 2015012520 A 20160112; RU 2015143177 A 20170418; TW 201437635 A 20141001
DOCDB simple family (application)
US 2014023695 W 20140311; AU 2014248949 A 20140311; BR 112015022820 A 20140311; CA 2904418 A 20140311; CN 201480026826 A 20140311; EP 14778792 A 20140311; IL 24115615 A 20150903; JP 2016501318 A 20140311; KR 20157028347 A 20140311; MX 2015012520 A 20140311; RU 2015143177 A 20140311; TW 103108591 A 20140311