EP 2975023 B1 20180530 - GUANIDINOBENZOIC ACID ESTER COMPOUND
Title (en)
GUANIDINOBENZOIC ACID ESTER COMPOUND
Title (de)
GUANIDIN-BENZOESÄURE-ESTERVERBINDUNG
Title (fr)
COMPOSÉ ESTER D'ACIDE GUANIDINOBENZOÏQUE
Publication
Application
Priority
- JP 2013050011 A 20130313
- JP 2014056601 W 20140313
Abstract (en)
[origin: EP2975023A1] [Problem] To provide a compound which is useful as an agent for preventing and/or treating kidney diseases. [Means for Solution] The present inventors have studied compounds having a trypsin inhibitory activity, and have confirmed that a guanidinobenzoic acid ester compound has a trypsin inhibitory activity, thereby completing the present invention. The guanidinobenzoic acid ester compound of the present invention can be used as an agent for preventing and/or treating kidney diseases (for example, chronic kidney disease, acute glomerulonephritis, acute kidney injury, and the like) as an agent which will substitute low-protein diet therapy, and/or as an agent for preventing and/or treating trypsin-related diseases (for example, chronic pancreatitis, gastroesophageal reflux disease, hepatic encephalopathy, influenza, and the like).
IPC 8 full level
C07D 333/40 (2006.01); A61K 31/24 (2006.01); A61K 31/343 (2006.01); A61K 31/381 (2006.01); A61K 31/472 (2006.01); A61P 13/12 (2006.01); C07C 279/18 (2006.01); C07D 217/26 (2006.01); C07D 307/81 (2006.01); C07D 333/24 (2006.01); C07D 333/68 (2006.01); C07D 333/70 (2006.01)
CPC (source: EP RU US)
A61K 31/24 (2013.01 - EP RU US); A61K 31/343 (2013.01 - EP RU US); A61K 31/381 (2013.01 - EP RU US); A61K 31/472 (2013.01 - EP RU US); A61P 13/00 (2018.01 - EP); A61P 13/12 (2018.01 - EP); C07C 279/18 (2013.01 - EP RU US); C07D 217/26 (2013.01 - EP RU US); C07D 307/81 (2013.01 - EP RU US); C07D 333/24 (2013.01 - EP RU US); C07D 333/40 (2013.01 - EP RU US); C07D 333/68 (2013.01 - EP RU US); C07D 333/70 (2013.01 - EP RU US); C07C 2602/08 (2017.05 - EP US); C07C 2602/10 (2017.05 - EP US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
EP 2975023 A1 20160120; EP 2975023 A4 20160803; EP 2975023 B1 20180530; AU 2014230583 A1 20151001; AU 2014230583 B2 20170928; BR 112015022762 A2 20170718; BR 112015022762 A8 20180123; BR 112015022762 B1 20220816; CA 2905606 A1 20140918; CA 2905606 C 20210309; CN 105051008 A 20151111; CN 105051008 B 20180529; CY 1120552 T1 20190710; DK 2975023 T3 20180820; ES 2684045 T3 20181001; HK 1216246 A1 20161028; HR P20181371 T1 20181019; HU E039526 T2 20190128; IL 241541 B 20190630; JP 6314129 B2 20180418; JP WO2014142219 A1 20170216; KR 102145649 B1 20200818; KR 20150130392 A 20151123; LT 2975023 T 20180810; MX 2015012604 A 20161013; MY 194604 A 20221206; PH 12015502023 A1 20160118; PH 12015502023 B1 20160118; PL 2975023 T3 20181130; PT 2975023 T 20180727; RS 57568 B1 20181031; RU 2015143562 A 20170419; RU 2661895 C2 20180723; SG 10201707504V A 20171030; SG 11201507411T A 20151029; SI 2975023 T1 20181030; TR 201809418 T4 20180723; TW 201522291 A 20150616; TW I666196 B 20190721; UA 118668 C2 20190225; US 2016031847 A1 20160204; US 9969709 B2 20180515; WO 2014142219 A1 20140918; ZA 201506745 B 20170426
DOCDB simple family (application)
EP 14763790 A 20140313; AU 2014230583 A 20140313; BR 112015022762 A 20140313; CA 2905606 A 20140313; CN 201480014813 A 20140313; CY 181100832 T 20180809; DK 14763790 T 20140313; ES 14763790 T 20140313; HK 16104215 A 20160413; HR P20181371 T 20180827; HU E14763790 A 20140313; IL 24154115 A 20150910; JP 2014056601 W 20140313; JP 2015505541 A 20140313; KR 20157027906 A 20140313; LT 14763790 T 20140313; MX 2015012604 A 20140313; MY PI2015703099 A 20140313; PH 12015502023 A 20150909; PL 14763790 T 20140313; PT 14763790 T 20140313; RS P20180861 A 20140313; RU 2015143562 A 20140313; SG 10201707504V A 20140313; SG 11201507411T A 20140313; SI 201430865 T 20140313; TR 201809418 T 20140313; TW 103109057 A 20140313; UA A201509922 A 20140313; US 201414775274 A 20140313; ZA 201506745 A 20150911