Global Patent Index - EP 2977375 A1

EP 2977375 A1 20160127 - Amino-substituted isoxazoles

Title (en)

Amino-substituted isoxazoles

Title (de)

Aminosubstituierte Isoxazole

Title (fr)

Isoxazoles substitués par amino

Publication

EP 2977375 A1 20160127 (EN)

Application

EP 14178455 A 20140725

Priority

EP 14178455 A 20140725

Abstract (en)

The present invention relates to amino-substituted isoxazoles of general formula (I) : in which A, R1 and R2 are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.

IPC 8 full level

A61K 31/42 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01)

CPC (source: EP)

C07D 413/12 (2013.01); C07D 413/14 (2013.01)

Citation (applicant)

  • WO 2011063908 A1 20110603 - BAYER SCHERING PHARMA AG [DE], et al
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  • WO 02068406 A2 20020906 - AMGEN INC [US]
  • US 5023252 A 19910611 - HSEIH DEAN [US]
  • US 5011472 A 19910430 - AEBISCHER PATRICK [US], et al
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Citation (search report)

  • [XA] WO 2013169889 A1 20131114 - ANVYL LLC [US]
  • [E] WO 2014118186 A1 20140807 - BAYER PHARMA AG [DE]
  • [XA] KISELYOV ET AL: "ortho-Substituted azoles as selective and dual inhibitors of VEGF receptors 1 and 2", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 17, no. 5, 14 February 2007 (2007-02-14), pages 1369 - 1375, XP005888482, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2006.11.087
  • [XA] STANISLW RYNG ET AL: "Synthesis and Structure Elucidation of 5-Aminomethinimino-3-methyl-4-isoxazolecarboxylic Acid Phenylamides and Their Immunological Activity", ARCHIV DER PHARMAZIE, vol. 330, no. 11, 1 January 1997 (1997-01-01), pages 319 - 326, XP055070292, ISSN: 0365-6233, DOI: 10.1002/ardp.19973301102

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

DOCDB simple family (publication)

EP 2977375 A1 20160127

DOCDB simple family (application)

EP 14178455 A 20140725