EP 2989466 A4 20161214 - ANALYTICAL METHOD FOR INCREASING SUSCEPTIBILITY OF MOLECULAR TARGETED THERAPY IN HEPATOCELLULAR CARCINOMA
Title (en)
ANALYTICAL METHOD FOR INCREASING SUSCEPTIBILITY OF MOLECULAR TARGETED THERAPY IN HEPATOCELLULAR CARCINOMA
Title (de)
ANALYTISCHES VERFAHREN ZUR ERHÖHUNG DER SUSZEPTIBILITÄT EINER MOLEKULAREN GEZIELTEN THERAPIE BEI EINEM HEPATOZELLULÄREN KARZINOM
Title (fr)
PROCÉDÉ ANALYTIQUE POUR AUGMENTER LA SENSIBILITÉ D'UNE THÉRAPIE MOLÉCULAIRE CIBLÉE DANS UN CARCINOME HÉPATOCELLULAIRE
Publication
Application
Priority
- KR 20130046279 A 20130425
- KR 2014003281 W 20140416
Abstract (en)
[origin: WO2014175593A1] The present invention provides an analytical method for determining whether a hepatocellular carcinoma patient has susceptibility or resistance to sorafenib treatment. It has been found by the present invention that FGFR1 has relationship with susceptibility to sorafenib treatment. Therefore, the analysis on the mRNA expression of FGFR1, optionally along with the mRNA expressions of other biomarkers (i.e., VEGFR2, PDGFRβ, c-KIT, c-RAF, EGFR, and/or mTOR) makes it possible to select a patient having susceptibility to sorafenib treatment and a patient having resistance to sorafenib treatment before employing molecular targeted therapy with sorafenib.
IPC 8 full level
G01N 33/574 (2006.01); C12N 15/11 (2006.01); C12Q 1/68 (2006.01)
CPC (source: CN EP KR US)
C12Q 1/6886 (2013.01 - CN EP KR US); C12Q 2600/106 (2013.01 - CN EP US); C12Q 2600/158 (2013.01 - CN EP US)
Citation (search report)
- [IY] EP 2527467 A2 20121128 - BRISTOL MYERS SQUIBB CO [US]
- [A] US 2007105142 A1 20070510 - WILHELM SCOTT [US]
- [Y] ABOU-ALFA GHASSAN K ET AL: "Phase II study of sorafenib in patients with advanced hepatocellular carcinoma", JOURNAL OF CLINICAL ONCOLOGY, AMERICAN SOCIETY OF CLINICAL ONCOLOGY, US, vol. 24, no. 26, 10 September 2006 (2006-09-10), pages 4293 - 4300, XP002540848, ISSN: 0732-183X, DOI: 10.1200/JCO.2005.01.3441
- See references of WO 2014175593A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2014175593 A1 20141030; CN 105074467 A 20151118; CN 105074467 B 20180615; EP 2989466 A1 20160302; EP 2989466 A4 20161214; EP 2989466 B1 20181031; JP 2016518837 A 20160630; JP 6489658 B2 20190327; KR 102200344 B1 20210111; KR 20140128865 A 20141106; US 10017823 B2 20180710; US 2015376715 A1 20151231
DOCDB simple family (application)
KR 2014003281 W 20140416; CN 201480008734 A 20140416; EP 14788980 A 20140416; JP 2016510611 A 20140416; KR 20140045164 A 20140416; US 201414765304 A 20140416