Global Patent Index - EP 2991650 A4

EP 2991650 A4 20170125 - METHODS FOR THE TREATMENT OF CANCER

Title (en)

METHODS FOR THE TREATMENT OF CANCER

Title (de)

VERFAHREN ZUR BEHANDLUNG VON KREBS

Title (fr)

MÉTHODES DE TRAITEMENT DU CANCER

Publication

EP 2991650 A4 20170125 (EN)

Application

EP 14791444 A 20140502

Priority

  • US 201361819505 P 20130503
  • US 2014036651 W 20140502

Abstract (en)

[origin: WO2014179738A1] Described herein are methods for the treatment of cancer in a subject. In particular, methods are provided for the treatment of lung cancer with a combination of entinostat and an EGFR inhibitor, or the treatment of breast cancer with a combination of entinostat and an aromatase inhibitor. Furthermore, a food effect was evident for the oral administration of entinostat.

IPC 8 full level

A61K 31/4406 (2006.01); A61K 31/5685 (2006.01); A61P 35/00 (2006.01)

CPC (source: EP)

A61K 31/4406 (2013.01); A61K 31/5685 (2013.01); A61P 5/32 (2017.12); A61P 11/00 (2017.12); A61P 15/00 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12)

Citation (search report)

  • [XY] L. GORE ET AL: "A Phase I and Pharmacokinetic Study of the Oral Histone Deacetylase Inhibitor, MS-275, in Patients with Refractory Solid Tumors and Lymphomas", CLINICAL CANCER RESEARCH, vol. 14, no. 14, 15 July 2008 (2008-07-15), US, pages 4517 - 4525, XP055323917, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-07-1461
  • [I] ANONYMOUS: "NCT01594398 on 2012_07_31: ClinicalTrials.gov Archive", 31 July 2012 (2012-07-31), XP055323902, Retrieved from the Internet <URL:https://clinicaltrials.gov/archive/NCT01594398/2012_07_31> [retrieved on 20161129]
  • [IY] S. KUMMAR ET AL: "Phase I Trial of MS-275, a Histone Deacetylase Inhibitor, Administered Weekly in Refractory Solid Tumors and Lymphoid Malignancies", CLINICAL CANCER RESEARCH, vol. 13, no. 18, 15 September 2007 (2007-09-15), US, pages 5411 - 5417, XP055323928, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-07-0791
  • [YA] NILOFER AZAD ET AL: "The future of epigenetic therapy in solid tumours-lessons from the past", NATURE REVIEWS CLINICAL ONCOLOGY, vol. 10, no. 5, 2 April 2013 (2013-04-02), NY, US, pages 256 - 266, XP055324023, ISSN: 1759-4774, DOI: 10.1038/nrclinonc.2013.42
  • See references of WO 2014179738A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2014179738 A1 20141106; CN 105492007 A 20160413; EP 2991650 A1 20160309; EP 2991650 A4 20170125; HK 1223547 A1 20170804; JP 2016522188 A 20160728; JP 2019112416 A 20190711; JP 6860949 B2 20210421; KR 102337598 B1 20211210; KR 20160003182 A 20160108

DOCDB simple family (application)

US 2014036651 W 20140502; CN 201480038420 A 20140502; EP 14791444 A 20140502; HK 16111783 A 20161012; JP 2016512076 A 20140502; JP 2019026073 A 20190215; KR 20157033947 A 20140502