Global Patent Index - EP 2992086 A4

EP 2992086 A4 20161207 - MODULATION OF REGULATORY T CELL FUNCTION VIA PROTEIN KINASE C-ETA

Title (en)

MODULATION OF REGULATORY T CELL FUNCTION VIA PROTEIN KINASE C-ETA

Title (de)

MODULATION DER FUNKTION REGULATORISCHER T-ZELLEN MITHILFE VON PROTEINKINASE-C-ETA

Title (fr)

MODULATION DE LA FONCTION RÉGULATRICE DES CELLULES T PAR L'INTERMÉDIAIRE D'UNE PROTÉINE KINASE C-ETA

Publication

EP 2992086 A4 20161207 (EN)

Application

EP 14791378 A 20140430

Priority

  • US 201361817754 P 20130430
  • US 2014036237 W 20140430

Abstract (en)

[origin: WO2014179491A2] Compounds, uses and methods for modulating an immune response are provided. In particular, modulating the interaction of PKCη with CTLA-4 can modulate an immune response. For example, modulating activity or expression of PKCη, and/or modulating activity or expression of CTLA-4, can be used to modulate interaction of PKCη with CTLA-4, thereby modulating an immune response.

IPC 8 full level

C12N 5/00 (2006.01); A61K 38/00 (2006.01); A61K 38/16 (2006.01); C12N 5/02 (2006.01); C12N 15/11 (2006.01)

CPC (source: EP US)

A61K 39/39 (2013.01 - EP US); C07K 14/70521 (2013.01 - EP US); C07K 16/2818 (2013.01 - US); C07K 16/40 (2013.01 - US); A61K 38/00 (2013.01 - EP US); A61K 2039/505 (2013.01 - EP US); C07K 2317/31 (2013.01 - US); C12N 9/12 (2013.01 - EP US); C12Y 207/11013 (2013.01 - EP US)

Citation (search report)

  • [XI] WO 2011083481 A2 20110714 - HEALOR LTD, et al
  • [XI] WO 2005014612 A1 20050217 - BRIGHAM & WOMENS HOSPITAL [US], et al
  • [XI] WO 2010026565 A1 20100311 - UNIV BEN GURION [IL], et al
  • [XI] WO 2010117055 A1 20101014 - UNIV KYUSHU NAT UNIV CORP [JP], et al
  • [XI] T. FISCHER ET AL: "Phase IIB Trial of Oral Midostaurin (PKC412), the FMS-Like Tyrosine Kinase 3 Receptor (FLT3) and Multi-Targeted Kinase Inhibitor, in Patients With Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome With Either Wild-Type or Mutated FLT3", JOURNAL OF CLINICAL ONCOLOGY, vol. 28, no. 28, 23 August 2010 (2010-08-23), US, pages 4339 - 4345, XP055290517, ISSN: 0732-183X, DOI: 10.1200/JCO.2010.28.9678
  • [XI] M. A. CURRAN ET AL: "PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 107, no. 9, 2 March 2010 (2010-03-02), pages 4275 - 4280, XP055067204, ISSN: 0027-8424, DOI: 10.1073/pnas.0915174107
  • [AP] KOK-FAI KONG ET AL: "Protein kinase C-[eta] controls CTLA-4-mediated regulatory T cell function", NATURE IMMUNOLOGY, vol. 15, no. 5, 6 April 2014 (2014-04-06), GB, pages 465 - 472, XP055290520, ISSN: 1529-2908, DOI: 10.1038/ni.2866
  • [I] FU GUO ET AL: "Protein kinase C [eta] is required for T cell activation and homeostatic proliferation.", SCIENCE SIGNALING 06 DEC 2011, vol. 4, no. 202, 6 December 2011 (2011-12-06), pages ra84, XP008182073, ISSN: 1937-9145, DOI: 10.1126/scisignal.2002058
  • [A] EMILY J QUANN ET AL: "A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells", NATURE IMMUNOLOGY, vol. 12, no. 7, 22 May 2011 (2011-05-22), GB, pages 647 - 654, XP055313295, ISSN: 1529-2908, DOI: 10.1038/ni.2033
  • See references of WO 2014179491A2

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2014179491 A2 20141106; WO 2014179491 A3 20150604; EP 2992086 A2 20160309; EP 2992086 A4 20161207; EP 2992086 B1 20200930; US 2016075753 A1 20160317

DOCDB simple family (application)

US 2014036237 W 20140430; EP 14791378 A 20140430; US 201414888313 A 20140430