EP 2994160 B1 20190703 - TREATMENT OF ALZHEIMER'S DISEASE SUBPOPULATIONS WITH POOLED IMMUNOGLOBULIN G
Title (en)
TREATMENT OF ALZHEIMER'S DISEASE SUBPOPULATIONS WITH POOLED IMMUNOGLOBULIN G
Title (de)
BEHANDLUNG VON MORBUS-ALZHEIMER-SUBPOPULATIONEN MIT GEPOOLTEM IMMUNGLOBULIN G
Title (fr)
TRAITEMENT DE SOUS-POPULATIONS ATTEINTES DE LA MALADIE D'ALZHEIMER AVEC DE L'IMMUNOGLOBULINE G RASSEMBLÉE
Publication
Application
Priority
- US 201361855062 P 20130506
- US 201361833447 P 20130610
- US 201361844732 P 20130710
- US 201361886464 P 20131003
- US 2014036848 W 20140505
Abstract (en)
[origin: US2014328856A1] The present invention provides, among other aspects, methods for the treatment of Alzheimer's disease in a subject in need thereof, the method including administration of a therapeutically effective amount of a pooled human immunoglobulin G (IgG) composition to a subject with moderately severe Alzheimer's disease, a subject carrying an ApoE4 allele, or both, where the amount of pooled human IgG is from 300 mg/kg to 800 mg/kg body weight of the subject per two week period, and where the amount is administered in one or more doses during the two week period after initiation of a therapeutic regimen. Also provided, are methods for selecting a treatment regimen for a subject with Alzheimer's disease, including diagnosing the severity of the Alzheimer's disease, determining if the subject carries an APOE4 allele, or both, and assigning a treatment regimen including administration of pooled human immunoglobulin G and/or an anti-beta amyloid monoclonal antibody.
IPC 8 full level
A61K 39/395 (2006.01); A61K 38/47 (2006.01); A61K 39/00 (2006.01); C07K 16/06 (2006.01); C07K 16/18 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP US)
A61K 38/47 (2013.01 - EP US); A61K 39/39516 (2013.01 - EP US); A61P 25/28 (2018.01 - EP US); C07K 16/00 (2013.01 - EP US); C07K 16/06 (2013.01 - EP US); C07K 16/065 (2013.01 - EP US); C07K 16/18 (2013.01 - US); G01N 33/6896 (2013.01 - EP US); A61K 2039/505 (2013.01 - EP US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
US 2014328856 A1 20141106; AU 2014262890 A1 20151126; AU 2014262890 B2 20190131; AU 2019202459 A1 20190502; AU 2019202459 B2 20200723; AU 2020257034 A1 20201112; AU 2024201051 A1 20240314; DK 2994160 T3 20190812; EP 2994160 A1 20160316; EP 2994160 B1 20190703; EP 3552624 A1 20191016; ES 2740127 T3 20200205; HR P20191383 T1 20200207; HU E044737 T2 20191128; JP 2016518411 A 20160623; JP 6424210 B2 20181114; LT 2994160 T 20190826; PL 2994160 T3 20191031; PT 2994160 T 20190807; US 2019144530 A1 20190516; US 2021238267 A1 20210805; WO 2014182631 A1 20141113
DOCDB simple family (application)
US 201414270192 A 20140505; AU 2014262890 A 20140505; AU 2019202459 A 20190409; AU 2020257034 A 20201019; AU 2024201051 A 20240219; DK 14730660 T 20140505; EP 14730660 A 20140505; EP 19175106 A 20140505; ES 14730660 T 20140505; HR P20191383 T 20190731; HU E14730660 A 20140505; JP 2016512995 A 20140505; LT 14730660 T 20140505; PL 14730660 T 20140505; PT 14730660 T 20140505; US 2014036848 W 20140505; US 201916247141 A 20190114; US 202117234658 A 20210419