EP 2997031 A1 20160323 - PROCESS FOR THE PREPARATION OF HIGH PURITY AMORPHOUS PEMETREXED DISODIUM AND CRYSTALLINE FORMS OF N-[4-[2-(2-AMINO-4,7-DIHYDRO-4-OXO-3H-PYRROLO[2,3- D]PYRIMIDIN-5-YL)ETHYL]BENZOYL]-L-GLUTAMIC ACID
Title (en)
PROCESS FOR THE PREPARATION OF HIGH PURITY AMORPHOUS PEMETREXED DISODIUM AND CRYSTALLINE FORMS OF N-[4-[2-(2-AMINO-4,7-DIHYDRO-4-OXO-3H-PYRROLO[2,3- D]PYRIMIDIN-5-YL)ETHYL]BENZOYL]-L-GLUTAMIC ACID
Title (de)
VERFAHREN ZUR HERSTELLUNG VON HOCHREINEM AMORPHEM PEMETREXED-DINATRIUM UND KRISTALLINEN FORMEN VON N-[4-[2-(2-AMINO-4,7-DIHYDRO-4-OXO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)ETHYL]BENZOYL]-L-GLUTAMINSÄURE
Title (fr)
PROCÉDÉ POUR LA PRÉPARATION DE PEMETREXED DISODIQUE AMORPHE DE HAUTE PURETÉ ET FORMES CRISTALLINES DE L'ACIDE N-[4-[2-(2-AMINO-4,7-DIHYDRO-4-OXO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)ÉTHYL]BENZOYL]-L-GLUTAMIQUE
Publication
Application
Priority
- PL 40394213 A 20130517
- PL 40808914 A 20140430
- PL 2014000053 W 20140516
Abstract (en)
[origin: WO2014185797A1] A process for the preparation of high purity amorphous pemetrexed disodium is characterized by reacting N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3- d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid with molar shortage of sodium cations generating compound in regard to carboxyl groups of free acid, under anhydrous conditions. Preferably, in that process pure crystalline Form 1 or Form 2 of N-[4-[2-(2- amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, containing from 27 to 31% of dimethyl sulfoxide, is used.
IPC 8 full level
C07D 487/04 (2006.01)
CPC (source: EP)
C07D 487/04 (2013.01)
Citation (search report)
See references of WO 2014185797A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
DOCDB simple family (application)
PL 2014000053 W 20140516; EP 14732453 A 20140516