Global Patent Index - EP 3000471 A1

EP 3000471 A1 20160330 - Novel immunostimulatory molecules

Title (en)

Novel immunostimulatory molecules

Title (de)

Neue immunstimulierende Moleküle

Title (fr)

Nouvelles molécules immunostimulantes

Publication

EP 3000471 A1 20160330 (EN)

Application

EP 14186723 A 20140928

Priority

EP 14186723 A 20140928

Abstract (en)

The present invention relates to novel immunostimulatory molecules which are derived from the intestinal protozoan Entamoeba histolytica. The compounds have been found to be useful for enhancing and/or inducing an immune response in a subject in need thereof. Specifically, the compounds have been found to be useful for the treatment of cancer diseases, such as breast cancer, and parasitic diseases, such as leishmaniasis. The invention also provides pharmaceutical compositions comprising the novel compounds.

IPC 8 full level

A61K 31/683 (2006.01); A61K 31/7034 (2006.01); A61K 35/15 (2015.01); A61P 31/00 (2006.01); A61P 33/00 (2006.01); A61P 33/02 (2006.01); A61P 35/00 (2006.01); C07F 9/10 (2006.01); C07H 15/20 (2006.01)

CPC (source: EP US)

A61K 31/683 (2013.01 - EP US); A61K 31/7034 (2013.01 - EP US); A61K 35/15 (2013.01 - EP US); A61K 39/39 (2013.01 - EP US); A61K 39/4615 (2023.05 - EP); A61K 39/4622 (2023.05 - EP); A61K 39/4634 (2023.05 - EP); A61K 39/4644 (2023.05 - EP); A61P 31/00 (2018.01 - EP); A61P 33/00 (2018.01 - EP); A61P 33/02 (2018.01 - EP); A61P 35/00 (2018.01 - EP); C07F 9/117 (2013.01 - EP US); C07F 9/6552 (2013.01 - EP US); C07F 9/65586 (2013.01 - EP US); C07H 15/207 (2013.01 - EP US); A61K 2039/5154 (2013.01 - US); A61K 2039/54 (2013.01 - US); A61K 2039/55511 (2013.01 - EP US); A61K 2239/49 (2023.05 - EP); Y02A 50/30 (2018.01 - EP US)

Citation (applicant)

  • IWASAKI, T. ET AL., CHEM. EUR. J. 2013, vol. 19, 2013, pages 2956 - 2960
  • IWASAKI, T. ET AL., CHEM. EUR. J., vol. 19, 2013, pages 2956 - 2960
  • SABURI, H. ET AL., ANGEW. CHEM. INT. ED., vol. 44, 2005, pages 1730 - 1732
  • ARIAS JL: "Liposomes in drug delivery: a patent review (2007-present", EXPERT OPIN THER PAT., vol. 23, no. 11, 2013, pages 1399 - 414
  • BARROS NB ET AL.: "Liposomal-lupane system as alternative chemotherapy against cutaneous leishmaniasis: macrophage as target cell", EXPERIMENTAL PARASITOLOGY, vol. 135, 2013, pages 337 - 343
  • BLUM J ET AL.: "Local or systemic treatment for New World cutaneous leishmaniasis? Re-evaluating the evidence for the risk of mucosal leishmaniasis", INTERNATIONAL HEALTH, vol. 4, 2012, pages 153 - 163
  • ISHIKAWA A ET AL.: "A phase I study of a-galactosylceramide (KRN-7000)-pulsed dendritic cells in patients with advanced and recurrent non-small cell lung cancer", CLINICAL CANCER RESEARCH, vol. 11, no. 5, 2005, pages 1919 - 7, XP055220329, DOI: doi:10.1158/1078-0432.CCR-04-1453
  • LAURENT X ET AL.: "Switching Invariant Natural Killer T (iNKT) Cell Response from Anti-cancerous to Anti-Inflammatory Effect: Molecular Bases", JOURNAL OF MEDICINAL CHEMISTRY, vol. 57, 2014, pages 5489 - 5508
  • LOTTER H ET AL.: "Natural killer T cells activated by a lipopeptidephosphoglycan from Entamoeba histolytica are critically important to control amebic liver abscess", PLOS PATHOG, vol. 5, 2009, pages E1000434
  • LOTTER H ET AL.: "Testosterone increases susceptibility to amebic liver abscess in mice and mediates inhibition ofIFNgamma secretion in natural killer T cells", PLOS ONE, vol. 8, 2013, pages E55694
  • NEUMAYR AL ET AL.: "Clinical aspects and management of cutaneous leishmaniasis in rheumatoid patients treated with TNF-alpha antagonists", TRAVEL MEDICINE AND INFECTIOUS DISEASE, vol. 11, 2013, pages 412 - 420
  • SANDBERG JK ET AL.: "Dominant effector memory characteristics, capacity for dynamic adaptive expansion, and sex bias in the innate Valpha24NKT cell compartment", EUR J IMMUNOL, vol. 33, no. 3, 2003, pages 588 - 96
  • SOSA N ET AL.: "Randomized, double-blinded, phase 2 trial of WR 279,396 (paromomycin and gentamicin) for cutaneous leishmaniasis in Panama", THE AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, vol. 89, 2013, pages 557 - 563
  • TANAKA, S. ET AL., ORG. LETT., vol. 4, 2004, pages 1873 - 1875
  • UCHIDA T ET AL.: "Phase I study of alpha-galactosylceramide-pulsed antigen presenting cells administration to the nasal submucosa in unresectable or recurrent head and neck cancer", CANCER IMMUNOL. IMMMUNOTHER., vol. 57, 2008, pages 337 - 345, XP019586687
  • WEGWITZ F ET AL.: "Tumorigenic WAP-T mouse mammary carcinoma cells: a model for a self-reproducing homeostatic cancer cell system", PLOS ONE, vol. 5, 2010, pages E12103
  • XU, YJ ET AL., J. ORG. CHEM., vol. 71, 2006, pages 4919 - 4928

Citation (search report)

  • [X] EP 0534544 A1 19930331 - MERCK & CO INC [US]
  • [Y] WO 2011006084 A2 20110113 - UNIV SOUTH ALABAMA [US], et al
  • [Y] US 2011135684 A1 20110609 - LOTTEAU VINCENT [FR], et al
  • [A] EP 1329219 A1 20030723 - KIMIGAFUCHI GAKUEN [JP], et al
  • [A] WO 2012086406 A1 20120628 - KAO CORP [JP], et al
  • [XDY] HANNELORE LOTTER ET AL: "Natural Killer T Cells Activated by a Lipopeptidophosphoglycan from Entamoeba histolytica Are Critically Important To Control Amebic Liver Abscess", PLOS PATHOGENS, vol. 5, no. 5, 15 May 2009 (2009-05-15), pages e1000434, XP055178811, DOI: 10.1371/journal.ppat.1000434
  • [Y] GHANEKAR SMITA A ET AL: "Phenotype and in vitro function of mature MDDC generated from cryopreserved PBMC of cancer patients are equivalent to those from healthy donors", JOURNAL OF IMMUNE BASED THERAPIES AND VACCINES, BIOMED CENTRAL LTD., LONDON, GB, vol. 5, no. 1, 3 May 2007 (2007-05-03), pages 7, XP021024503, ISSN: 1476-8518, DOI: 10.1186/1476-8518-5-7

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

DOCDB simple family (publication)

EP 3000471 A1 20160330; BR 112017006177 A2 20171219; EP 3197461 A1 20170802; RU 2017114429 A 20181029; RU 2017114429 A3 20190430; US 2017298083 A1 20171019; WO 2016046419 A1 20160331; ZA 201702925 B 20181128

DOCDB simple family (application)

EP 14186723 A 20140928; BR 112017006177 A 20150928; EP 15770891 A 20150928; EP 2015072292 W 20150928; RU 2017114429 A 20150928; US 201515513002 A 20150928; ZA 201702925 A 20170426