EP 3010909 A1 20160427 - SUBSTITUTED PHENYL-2,3-BENZODIAPEZINE
Title (en)
SUBSTITUTED PHENYL-2,3-BENZODIAPEZINE
Title (de)
SUBSTITUIERTE PHENYL-2,3-BENZODIAZEPINE
Title (fr)
PHÉNYL-2,3-BENZODIAPÉZINE SUBSTITUÉ
Publication
Application
Priority
- EP 13172351 A 20130617
- EP 2014062674 W 20140617
- EP 14730906 A 20140617
Abstract (en)
[origin: WO2014202578A1] The invention relates to BET-protein-inhibiting, in particular BRD4-inhibiting, substituted phenyl-2,3-benzodiazepines of general formula (I), in which X, R1a, R1b, R1c, R2, R3, R4, and R5 have the meanings specified in the description, to pharmaceutical agents containing the compounds according to the invention, and to the prophylactic and therapeutic use of said pharmaceutical agents for hyperproliferative diseases, in particular tumor diseases. The invention further relates to the use of BET protein inhibitors in benign hyperplasias, atherosclerotic diseases, sepsis, autoimmune diseases, vascular diseases, viral infections, neurodegenerative diseases, inflammatory diseases, atherosclerotic diseases, and male fertility control.
IPC 8 full level
C07D 403/12 (2006.01); A61K 31/551 (2006.01); A61P 25/00 (2006.01); C07D 243/02 (2006.01); C07D 401/12 (2006.01); C07D 413/12 (2006.01)
CPC (source: EP)
A61K 31/551 (2013.01); A61K 45/06 (2013.01); A61P 9/00 (2017.12); A61P 9/10 (2017.12); A61P 13/08 (2017.12); A61P 15/00 (2017.12); A61P 17/00 (2017.12); A61P 19/00 (2017.12); A61P 25/00 (2017.12); A61P 29/00 (2017.12); A61P 31/04 (2017.12); A61P 31/12 (2017.12); A61P 35/00 (2017.12); A61P 35/02 (2017.12); A61P 37/06 (2017.12); C07D 243/02 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); C07D 453/02 (2013.01)
Citation (search report)
See references of WO 2014202578A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2014202578 A1 20141224; CA 2915419 A1 20141224; CN 105492436 A 20160413; EP 3010909 A1 20160427; JP 2016521722 A 20160725
DOCDB simple family (application)
EP 2014062674 W 20140617; CA 2915419 A 20140617; CN 201480045607 A 20140617; EP 14730906 A 20140617; JP 2016518530 A 20140617