EP 3011331 A1 20160427 - GI PROTEIN PHOSPHORYLATION AS MARKER FOR SCOLIOSIS AND SCOLIOSIS PROGRESSION, METHODS OF INCREASING GIPCR SIGNALING IN SCOLIOTIC SUBJECTS
Title (en)
GI PROTEIN PHOSPHORYLATION AS MARKER FOR SCOLIOSIS AND SCOLIOSIS PROGRESSION, METHODS OF INCREASING GIPCR SIGNALING IN SCOLIOTIC SUBJECTS
Title (de)
GI-PROTEINPHOSPHORYLIERUNG ALS MARKER FÜR SKOLIOSE UND SKOLIOSEPROGRESSION SOWIE VERFAHREN ZUR ERHÖHUNG DER GIPCR-SIGNALISIERUNG BEI PERSONEN MIT SKOLIOSE
Title (fr)
PHOSPHORYLATION DE LA PROTÉINE GI EN TANT QUE MARQUEUR POUR LA SCOLIOSE ET POUR LA PROGRESSION DE LA SCOLIOSE, MÉTHODES D'AUGMENTATION DE LA SIGNALISATION GIPCR CHEZ DES SUJETS SCOLIOTIQUES
Publication
Application
Priority
- US 201361835839 P 20130617
- CA 2014050562 W 20140616
Abstract (en)
[origin: WO2014201557A1] Methods of stratifying a subject having or at risk for developing adolescent idiopathic scoliosis (AIS) into diagnostically or clinically useful subclasses are provided. The stratification is based on the subject's Giα protein serine phosphorylation profile and/or the degree of imbalance in G-protein coupled receptor responses to Giα and Gsα protein stimulation. In some embodiments, the methods involve detecting or determining the level of serine phosphorylated Giα1 and/or Giα3 proteins in the cell sample, and/or determining a ratio between the response to Giα protein stimulation and the response to Gsα protein stimulation from a biological sample from the subject. Methods for predicting the risk of an AIS subject for developing a severe scoliosis, for predicting the subject's responsiveness to bracing treatment, and for identifying therapeutically useful compounds are also provided, as well as kits therefor.
IPC 8 full level
G01N 33/48 (2006.01); A61K 31/18 (2006.01); A61K 31/404 (2006.01); A61K 31/4188 (2006.01); A61K 31/4427 (2006.01); A61K 31/4439 (2006.01); A61K 31/472 (2006.01); A61K 31/473 (2006.01); A61K 31/4745 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP US)
A61K 31/18 (2013.01 - EP US); A61K 31/4188 (2013.01 - EP US); A61K 31/4427 (2013.01 - EP US); A61K 31/4745 (2013.01 - EP US); G01N 33/6872 (2013.01 - EP US); G01N 33/6893 (2013.01 - EP US); G01N 2333/4704 (2013.01 - US); G01N 2440/14 (2013.01 - EP US); G01N 2800/10 (2013.01 - EP US); G01N 2800/38 (2013.01 - EP US); G01N 2800/50 (2013.01 - EP US); G01N 2800/52 (2013.01 - US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2014201557 A1 20141224; AU 2014284075 A1 20160107; CA 2914208 A1 20141224; CN 105378476 A 20160302; CN 105378476 B 20190510; EP 3011331 A1 20160427; EP 3011331 A4 20170510; EP 3011331 B1 20190313; HK 1220008 A1 20170421; KR 20160020552 A 20160223; US 2016139146 A1 20160519; US 2018284132 A1 20181004
DOCDB simple family (application)
CA 2014050562 W 20140616; AU 2014284075 A 20140616; CA 2914208 A 20140616; CN 201480040278 A 20140616; EP 14813743 A 20140616; HK 16108021 A 20160708; KR 20167001248 A 20140616; US 201414898766 A 20140616; US 201815960765 A 20180424