EP 3013370 A1 20160504 - DOUBLE BINDING CONSTRUCTS
Title (en)
DOUBLE BINDING CONSTRUCTS
Title (de)
DOPPELBINDUNGSKONSTRUKTE
Title (fr)
CONSTRUCTIONS À DOUBLE LIAISON
Publication
Application
Priority
- US 201361838721 P 20130624
- US 2014043907 W 20140624
Abstract (en)
[origin: WO2014210029A1] The disclosure provides methods and materials for improving the pharmacokinetic properties of drugs. For example, a construct is provided having a drug covalently joined to first and second ligands, or a drug covalently joined to a first ligand and a molecular weight increasing moiety. The ligands have affinity for binding partners, and in a physiological fluid, an equilibrium forms between bound and free forms of the construct. The constructs retain most of the drug's activity while simultaneously increasing half life.
IPC 8 full level
A61K 47/48 (2006.01)
CPC (source: EP)
A61K 47/542 (2017.07); A61K 47/551 (2017.07); A61K 47/60 (2017.07); A61K 47/64 (2017.07); A61K 47/643 (2017.07)
Citation (search report)
See references of WO 2014210029A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
DOCDB simple family (application)
US 2014043907 W 20140624; EP 14744395 A 20140624