Global Patent Index - EP 3016660 A4

EP 3016660 A4 20170222 - SHIP INHIBITION TO COMBAT OBESITY

Title (en)

SHIP INHIBITION TO COMBAT OBESITY

Title (de)

SHIP-HEMMUNG GEGEN FETTLEIBIGKEIT

Title (fr)

INHIBITION DE SHIP DANS LE CADRE DE LA LUTTE CONTRE L'OBÉSITÉ

Publication

EP 3016660 A4 20170222 (EN)

Application

EP 14820357 A 20140701

Priority

  • US 201361841738 P 20130701
  • US 201461940368 P 20140214
  • US 201462013361 P 20140617
  • US 2014045146 W 20140701

Abstract (en)

[origin: WO2015003003A1] The present invention relates to the use of SHIP1 inhibitors and pan-SHIP1/2 inhibitors in various methods, including, without limitation: (i) a method to treat obesity or reduce body fat of an obese subject; (ii) a method to limit bone development in a subject suffering from an osteopetrotic or sclerotic disease; (iii) a method to treat or prevent diabetes; (iv) a method to reduce glucose intolerance or insulin resistance; and (v) a method to lower cholesterol.

IPC 8 full level

A61K 31/565 (2006.01); A61K 31/56 (2006.01); A61P 3/00 (2006.01); A61P 3/04 (2006.01)

CPC (source: EP US)

A61K 31/4045 (2013.01 - EP US); A61K 31/4709 (2013.01 - EP US); A61K 31/473 (2013.01 - EP US); A61K 31/565 (2013.01 - EP US); A61K 31/566 (2013.01 - EP US); A61K 31/568 (2013.01 - EP US); A61K 31/5685 (2013.01 - EP US); A61K 31/575 (2013.01 - EP US); A61K 31/655 (2013.01 - EP US); A61K 31/713 (2013.01 - EP US); A61P 3/00 (2017.12 - EP); A61P 3/04 (2017.12 - EP); A61P 3/10 (2017.12 - EP); C12N 15/1137 (2013.01 - US); C12N 2310/14 (2013.01 - US); C12N 2310/141 (2013.01 - US)

Citation (search report)

  • [XI] WO 2004032880 A2 20040422 - ISIS PHARMACEUTICALS INC [US], et al
  • [X] WO 2009032321 A2 20090312 - GENAERA CORP [US], et al
  • [X] US 5710143 A 19980120 - SUZUKI KUNIO [JP], et al
  • [X] EP 0133995 A2 19850313 - RESEARCH CORP [US]
  • [A] MATTHEW D BLUNT ET AL: "Targeting PI3K isoforms and SHIP in the immune system: new therapeutics for inflammation and leukemia", CURRENT OPINION IN PHARMACOLOGY, vol. 12, no. 4, 1 August 2012 (2012-08-01), pages 444 - 451, XP055095312, ISSN: 1471-4892, DOI: 10.1016/j.coph.2012.02.015
  • [A] DIANE MATHIS: "Immunological Goings-on in Visceral Adipose Tissue", CELL METABOLISM, vol. 17, no. 6, 1 June 2013 (2013-06-01), United States, pages 851 - 859, XP055331435, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2013.05.008
  • [T] NEETU SRIVASTAVA ET AL: "A small-molecule inhibitor of SHIP1 reverses age- and diet-associated obesity and metabolic syndrome", JCI INSIGHT, vol. 1, no. 11, 21 July 2016 (2016-07-21), XP055331368, DOI: 10.1172/jci.insight.88544
  • See references of WO 2015003003A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2015003003 A1 20150108; AU 2014284360 A1 20160218; AU 2014284360 B2 20191010; AU 2014284360 B9 20191024; AU 2020200210 A1 20200206; CA 2953917 A1 20150108; CA 2953917 C 20211019; EP 3016660 A1 20160511; EP 3016660 A4 20170222; EP 3016660 B1 20200610; EP 3695841 A2 20200819; EP 3695841 A3 20201104; US 2016129017 A1 20160512; US 2020376005 A1 20201203

DOCDB simple family (application)

US 2014045146 W 20140701; AU 2014284360 A 20140701; AU 2020200210 A 20200110; CA 2953917 A 20140701; EP 14820357 A 20140701; EP 20167369 A 20140701; US 201414900719 A 20140701; US 201916724093 A 20191220