Global Patent Index - EP 3016964 A1

EP 3016964 A1 20160511 - METHOD FOR INCORPORATING PROTECTING ACETAL AND ACETAL ESTER GROUPS, AND ITS APPLICATION FOR THE PROTECTION OF HYDROXYL FUNCTION

Title (en)

METHOD FOR INCORPORATING PROTECTING ACETAL AND ACETAL ESTER GROUPS, AND ITS APPLICATION FOR THE PROTECTION OF HYDROXYL FUNCTION

Title (de)

VERFAHREN ZUR HERSTELLUNG VON SCHÜTZENDEM ACETAL UND ACETALESTERGRUPPEN UND DESSEN ANWENDUNG ZUM SCHUTZ EINER HYDROXYLFUNKTION

Title (fr)

PROCÉDÉ POUR INCORPORER DES GROUPES ACÉTAL ET ESTER D'ACÉTAL PROTECTEURS ET SON APPLICATION POUR LA PROTECTION DE LA FONCTION HYDROXYLE

Publication

EP 3016964 A1 20160511 (EN)

Application

EP 14723139 A 20140319

Priority

  • PL 40325613 A 20130321
  • PL 2014050012 W 20140319

Abstract (en)

[origin: WO2014148928A1] The present invention is the method for incorporation of acetal and acetal ester groups for protection of hydroxyl function. The method is applied in particular in the processes of RNA synthesis. The method can be employed in the synthesis of nucleosides with acetal and acetal ester groups for the protection of hydroxyl functions. The method according to the invention consists of the reaction of an organic compound containing at least one hydroxyl group, soluble in an aprotic solvent, with a compound of the general formula 1, R1 -S-CH2 -O-R2(1) in the presence of SnCl4, in an aprotic solvent. In the second aspect, the present invention is the method of protecting the hydroxyl function, particularly in position 2', in nucleoside derivatives, based on the incorporation of an acetal or acetal ester group.

IPC 8 full level

C07H 19/067 (2006.01); C07C 43/315 (2006.01); C07H 19/167 (2006.01)

CPC (source: EP)

C07H 19/067 (2013.01); C07H 19/167 (2013.01); Y02P 20/55 (2015.11)

Citation (search report)

See references of WO 2014148928A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

DOCDB simple family (publication)

WO 2014148928 A1 20140925; EP 3016964 A1 20160511; PL 221806 B1 20160531; PL 403256 A1 20140526

DOCDB simple family (application)

PL 2014050012 W 20140319; EP 14723139 A 20140319; PL 40325613 A 20130321