EP 3022223 B1 20190619 - ANTI-HUMAN PAPILLOMAVIRUS 16 E6 T CELL RECEPTORS
Title (en)
ANTI-HUMAN PAPILLOMAVIRUS 16 E6 T CELL RECEPTORS
Title (de)
T-ZELL-REZEPTOREN GEGEN MENSCHLICHES PAPILLOMAVIRUS 16 E6
Title (fr)
RÉCEPTEURS DE LYMPHOCYTES T ANTI-PAPILLOMAVIRUS HUMAIN 16 E6
Publication
Application
Priority
- US 201361846167 P 20130715
- US 2014046480 W 20140714
Abstract (en)
[origin: WO2015009606A1] Disclosed is a T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of human papillomavirus (HPV) 16 E6, E629-38. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells are also provided. Antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention are also provided. Also disclosed are methods of detecting the presence of a condition in a mammal and methods of treating or preventing a condition in a mammal, wherein the condition is cancer, HPV 16 infection, or HPV-positive premalignancy.
IPC 8 full level
C07K 14/725 (2006.01)
CPC (source: EP US)
A61K 35/17 (2013.01 - US); A61K 39/4611 (2023.05 - EP); A61K 39/4632 (2023.05 - EP); A61K 39/464491 (2023.05 - EP); A61K 39/464838 (2023.05 - EP); A61P 31/20 (2018.01 - EP); A61P 35/00 (2018.01 - EP); C07K 14/7051 (2013.01 - EP US); C07K 16/2809 (2013.01 - US); G01N 33/566 (2013.01 - US); A61K 38/00 (2013.01 - EP US); C07K 2317/34 (2013.01 - US); C07K 2319/00 (2013.01 - EP US); G01N 2333/7051 (2013.01 - US); G01N 2800/7028 (2013.01 - US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2015009606 A1 20150122; AU 2014290288 A1 20160204; AU 2014290288 B2 20180301; CA 2918216 A1 20150122; CA 2918216 C 20230321; CN 105452288 A 20160330; CN 105452288 B 20190813; CN 110511960 A 20191129; CN 110511960 B 20230523; EP 3022223 A1 20160525; EP 3022223 B1 20190619; EP 3572423 A1 20191127; EP 3572423 B1 20231206; ES 2745472 T3 20200302; ES 2973064 T3 20240618; JP 2016527230 A 20160908; JP 2020054359 A 20200409; JP 2022017292 A 20220125; JP 6628719 B2 20200115; JP 6959970 B2 20211105; JP 7223822 B2 20230216; US 10329339 B2 20190625; US 10913785 B2 20210209; US 11697676 B2 20230711; US 2016152681 A1 20160602; US 2018094041 A1 20180405; US 2019309043 A1 20191010; US 2021130433 A1 20210506; US 2023340066 A1 20231026; US 9822162 B2 20171121
DOCDB simple family (application)
US 2014046480 W 20140714; AU 2014290288 A 20140714; CA 2918216 A 20140714; CN 201480044286 A 20140714; CN 201910649441 A 20140714; EP 14748353 A 20140714; EP 19180239 A 20140714; ES 14748353 T 20140714; ES 19180239 T 20140714; JP 2016527006 A 20140714; JP 2019219105 A 20191203; JP 2021166407 A 20211008; US 201414905108 A 20140714; US 201715786966 A 20171018; US 201916408939 A 20190510; US 202117142486 A 20210106; US 202318323493 A 20230525