EP 3024500 A4 20170419 - CLINICAL MULTIMODALITY-TOOLS FOR PRE-AND INTRAOPERATIVE INSULINOMA DIAGNOSTICS
Title (en)
CLINICAL MULTIMODALITY-TOOLS FOR PRE-AND INTRAOPERATIVE INSULINOMA DIAGNOSTICS
Title (de)
MULTIMODALE KLINISCHE INSTRUMENTE ZUR PRÄ- UND INTRAOPERATIVEN INSULINOMDIAGNOSE
Title (fr)
OUTILS D'IMAGERIE MULTIMODALITÉ EN PRATIQUE CLINIQUE POUR DIAGNOSTICS DE L'INSULINOME PRÉOPÉRATOIRE ET INTRA-OPÉRATOIRE
Publication
Application
Priority
US 2014048277 W 20140725
Abstract (en)
[origin: WO2015013665A1] A chemical compound has the general formula: Ex4-linker-Sar(64Cu)-Fl in which Ex4 is an extendin-4 analog; linker is a polyethylene glycol (PEG) chain, for example formed with four ethylene glycol residues; Fl is a photoluminescent moiety, and Sar(64Cu) is an atom of copper-64 chelated in a sarcophagine moiety is useful as a multimodality imaging agent for detection and localization of insulinoma cells and β-cell masses.
IPC 8 full level
A61K 49/00 (2006.01); A61K 49/06 (2006.01); A61K 49/12 (2006.01); A61K 49/14 (2006.01); A61K 51/08 (2006.01); A61P 35/00 (2006.01)
CPC (source: EP US)
A61K 49/0032 (2013.01 - EP); A61K 49/0056 (2013.01 - EP); A61K 51/088 (2013.01 - EP US); A61P 35/00 (2017.12 - EP)
Citation (search report)
- [Y] WO 2012121746 A2 20120913 - GEN HOSPITAL CORP [US], et al
- [Y] US 2011206605 A1 20110825 - SAJI HIDEO [JP], et al
- [Y] T. REINER ET AL: "Accurate measurement of pancreatic islet -cell mass using a second-generation fluorescent exendin-4 analog", PROCEEDINGS NATIONAL ACADEMY OF SCIENCES PNAS, vol. 108, no. 31, 18 July 2011 (2011-07-18), US, pages 12815 - 12820, XP055353032, ISSN: 0027-8424, DOI: 10.1073/pnas.1109859108
- [Y] WU ZHANHONG ET AL: "64Cu Labeled sarcophagine exendin-4 for microPET imaging of glucagon like peptide-1 receptor expression", JOURNAL OF NUCLEAR MEDICINE, 1 May 2013 (2013-05-01), pages 1 - 2, XP055352993, Retrieved from the Internet <URL:http://jnm.snmjournals.org/content/54/supplement_2/1157.short> [retrieved on 20170308]
- [Y] SHUANGLONG LIU ET AL: "Efficient Construction of PET/Fluorescence Probe Based on Sarcophagine Cage: An Opportunity to Integrate Diagnosis with Treatment", MOLECULAR IMAGING AND BIOLOGY, SPRINGER-VERLAG, NE, vol. 14, no. 6, 3 April 2012 (2012-04-03), pages 718 - 724, XP035135415, ISSN: 1860-2002, DOI: 10.1007/S11307-012-0557-Z
- [A] TSUBERY H ET AL: "PROLONGING THE ACTION OF PROTEIN AND PEPTIDE DRUGS BY A NOVEL APPROACH OF REVERSIBLE POLYETHYLENE GLYCOL MODIFICATION", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 279, no. 37, 10 September 2004 (2004-09-10), pages 38118 - 38124, XP008040599, ISSN: 0021-9258, DOI: 10.1074/JBC.M405155200
- [XP] CHRISTIAN BRAND ET AL: "In Vivo Imaging of GLP-1R with a Targeted Bimodal PET/Fluorescence Imaging Agent", BIOCONJUGATE CHEMISTRY, vol. 25, no. 7, 23 May 2014 (2014-05-23), pages 1323 - 1330, XP055352994, ISSN: 1043-1802, DOI: 10.1021/bc500178d
- [YP] SUSAN M. CLARDY ET AL: "Fluorescent Exendin-4 Derivatives for Pancreatic [beta]-Cell Analysis", BIOCONJUGATE CHEMISTRY, vol. 25, no. 1, 15 January 2014 (2014-01-15), pages 171 - 177, XP055353198, ISSN: 1043-1802, DOI: 10.1021/bc4005014
- [YP] ZHANHONG WU ET AL: "64 Cu Labeled Sarcophagine Exendin-4 for MicroPET Imaging of Glucagon like Peptide-1 Receptor Expression", THERANOSTICS, vol. 4, no. 8, 1 January 2014 (2014-01-01), AU, pages 770 - 777, XP055353108, ISSN: 1838-7640, DOI: 10.7150/thno.7759
- See references of WO 2015013665A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2015013665 A1 20150129; EP 3024500 A1 20160601; EP 3024500 A4 20170419
DOCDB simple family (application)
US 2014048277 W 20140725; EP 14829114 A 20140725