EP 3039022 A1 20160706 - COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC AND BODY WEIGHT RELATED DISORDERS
Title (en)
COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC AND BODY WEIGHT RELATED DISORDERS
Title (de)
ZUSAMMENSETZUNGEN UND VERFAHREN ZUR BEHANDLUNG VON STOFFWECHSELSTÖRUNGEN UND GEWICHTSPROBLEMEN
Title (fr)
COMPOSITIONS ET PROCÉDÉS DE TRAITEMENT DE TROUBLES MÉTABOLIQUES ET TROUBLES ASSOCIÉS AU POIDS CORPOREL
Publication
Application
Priority
- US 201314013918 A 20130829
- US 201314052074 A 20131011
- US 201414270130 A 20140505
- US 2014053334 W 20140829
Abstract (en)
[origin: WO2015031710A1] The present invention relates to compounds, pharmaceutical compositions and formulations that have a tripartite structure A-B-C having having a piperidinyl, a pyrrolinyl or pyridinyl A ring, a thiazole B ring, and a phenyl C ring which may be further substituted independently. Also provided are methods for treating a metabolic disorder or a cell hyperproliferative disease with the compounds, pharmaceutical compositions and formulations described herein. Further provided are methods for reducing body weight or increasing thermogenesis during weight loss with the compounds of structure A-B-C, as described, or of structure Formula where R1 is H, Et, OMe or n-propyl; Y is CH or (formula); R2 is OH, OMe, or NH-i-Pr; R3 is H, F, or CI; and R4 is H, Me, CI, Br, F, OH, OBz, OCH2COOMe, OCH2COOH, NH2, NH-i-Pr, NHCOMe, NHSO2Me, NHBn (formula), OMe, NHBoc, (formula), NHTs, (formula), or (formula); or pharmaceutically acceptable salt or stereoisomer thereof or both.
IPC 8 full level
A61K 31/426 (2006.01); A61K 31/4439 (2006.01); A61P 3/00 (2006.01); C07D 213/06 (2006.01); C07D 231/06 (2006.01); C07D 277/22 (2006.01); C07D 277/24 (2006.01); C07D 277/66 (2006.01); C07D 417/04 (2006.01); C07D 417/14 (2006.01)
CPC (source: EP)
A61K 31/426 (2013.01); A61K 31/428 (2013.01); A61K 31/4439 (2013.01); A61P 1/16 (2017.12); A61P 3/00 (2017.12); A61P 3/04 (2017.12); A61P 3/06 (2017.12); A61P 3/10 (2017.12); A61P 9/10 (2017.12); A61P 9/12 (2017.12); A61P 11/06 (2017.12); A61P 35/00 (2017.12); A61P 35/02 (2017.12); A61P 35/04 (2017.12); A61P 43/00 (2017.12); C07D 213/06 (2013.01); C07D 213/76 (2013.01); C07D 231/06 (2013.01); C07D 235/14 (2013.01); C07D 277/22 (2013.01); C07D 277/24 (2013.01); C07D 277/52 (2013.01); C07D 277/66 (2013.01); C07D 295/192 (2013.01); C07D 417/04 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2015031710 A1 20150305; AU 2014312227 A1 20160421; CA 2922703 A1 20150305; CN 107074839 A 20170818; EP 3039022 A1 20160706; EP 3039022 A4 20170816; JP 2016534124 A 20161104
DOCDB simple family (application)
US 2014053334 W 20140829; AU 2014312227 A 20140829; CA 2922703 A 20140829; CN 201480058587 A 20140829; EP 14841043 A 20140829; JP 2016537878 A 20140829