EP 3049393 A1 20160803 - INHIBITORS OF POLYNUCLEOTIDE REPEAT-ASSOCIATED RNA FOCI AND USES THEREOF
Title (en)
INHIBITORS OF POLYNUCLEOTIDE REPEAT-ASSOCIATED RNA FOCI AND USES THEREOF
Title (de)
INHIBITOREN VON MIT POLYNUKLEOTIDWIEDERHOLUNGEN ASSOZIIERTEN RNA-FOCI UND VERWENDUNGEN DAVON
Title (fr)
INHIBITEURS D'AGRÉGATS D'ARN ASSOCIÉS À LA RÉPÉTITION DE POLYNUCLÉOTIDES ET LEURS UTILISATIONS
Publication
Application
Priority
CA 2013050730 W 20130925
Abstract (en)
[origin: WO2015042685A1] Compounds which inhibit the formation and/or accumulation of RNA foci, such as those due to polynucleotide repeats (e.g., trinucleotide repeats) are described herein. Also described herein are uses of such compounds, such as for the inhibition of the formation and accumulation such RNA foci, as well as for the treatment of polynucleotide repeat disorders (e.g., trinucleotide repeat disorders), such as myotonic dystrophy (e.g., DM1). Such compounds include compounds of formula 1, 1a, 1b, 2, 2a and (3) described herein.
IPC 8 full level
C07D 231/14 (2006.01); A61K 31/18 (2006.01); A61K 31/352 (2006.01); A61K 31/36 (2006.01); A61K 31/4155 (2006.01); A61K 31/4406 (2006.01); A61K 31/4453 (2006.01); A61K 31/496 (2006.01); A61K 31/5375 (2006.01); A61P 21/00 (2006.01); C07C 311/46 (2006.01); C07D 213/82 (2006.01); C07D 217/08 (2006.01); C07D 265/30 (2006.01); C07D 295/26 (2006.01); C07D 311/84 (2006.01); C07D 317/68 (2006.01); C07D 409/12 (2006.01); G01N 33/50 (2006.01)
CPC (source: EP)
A61K 31/18 (2013.01); A61K 31/352 (2013.01); A61K 31/36 (2013.01); A61K 31/415 (2013.01); A61K 31/4155 (2013.01); A61K 31/4406 (2013.01); A61K 31/451 (2013.01); A61K 31/454 (2013.01); A61K 31/496 (2013.01); A61K 31/5375 (2013.01); A61K 31/5377 (2013.01); A61K 31/63 (2013.01); A61P 21/00 (2017.12); C07C 311/46 (2013.01); C07D 231/14 (2013.01); C07D 409/12 (2013.01); G01N 33/502 (2013.01); C07C 2601/08 (2017.04); C07C 2603/74 (2017.04)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2015042685 A1 20150402; CA 2923503 A1 20150402; EP 3049393 A1 20160803; EP 3049393 A4 20170621
DOCDB simple family (application)
CA 2013050730 W 20130925; CA 2923503 A 20130925; EP 13894694 A 20130925