EP 3052476 B1 20200715 - SUBSTITUTED NICOTINIMIDE INHIBITORS OF BTK AND THEIR PREPARATION AND USE IN THE TREATMENT OF CANCER, INFLAMMATION AND AUTOIMMUNE DISEASE
Title (en)
SUBSTITUTED NICOTINIMIDE INHIBITORS OF BTK AND THEIR PREPARATION AND USE IN THE TREATMENT OF CANCER, INFLAMMATION AND AUTOIMMUNE DISEASE
Title (de)
SUBSTITUIERTE NICOTINIMIDINHIBITOREN VON BTK UND DEREN HERSTELLUNG UND VERWENDUNG ZUR BEHANDLUNG VON KREBS, ENTZÜNDUNGS- UND AUTOIMMUNERKRANKUNGEN
Title (fr)
INHIBITEURS DE NICOTINIMIDE SUBSTITUÉS DE BTK ET LEUR PRÉPARATION ET UTILISATION DANS LE TRAITEMENT DU CANCER, D'INFLAMMATIONS ET DES MALADIES AUTO-IMMUNES
Publication
Application
Priority
- US 201361884958 P 20130930
- CN 201310485048 A 20131016
- US 2014058084 W 20140929
Abstract (en)
[origin: WO2015048662A2] Compounds of Formula I, as shown below and defined herein: and pharmaceutically acceptable salts, syntheses, intermediates, formulations, and methods of treating diseases including cancer, inflammation, and autoimmune disease mediated at least in part by Bruton's Tyrosine Kinase (BTK).
IPC 8 full level
C07D 213/81 (2006.01); A61K 31/166 (2006.01); A61K 31/415 (2006.01); A61K 31/4155 (2006.01); A61K 31/421 (2006.01); A61K 31/426 (2006.01); A61K 31/4418 (2006.01); A61K 31/4427 (2006.01); A61K 31/4468 (2006.01); A61K 31/505 (2006.01); A61P 35/00 (2006.01); C07C 233/65 (2006.01); C07D 213/84 (2006.01); C07D 231/36 (2006.01); C07D 239/47 (2006.01); C07D 263/34 (2006.01); C07D 277/56 (2006.01); C07D 401/04 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01)
CPC (source: CN EP RU US)
A61K 31/444 (2013.01 - US); A61P 29/00 (2018.01 - EP); A61P 35/00 (2018.01 - EP US); A61P 37/06 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07D 211/34 (2013.01 - CN EP RU US); C07D 213/82 (2013.01 - CN EP RU US); C07D 231/14 (2013.01 - CN EP RU US); C07D 277/56 (2013.01 - CN EP RU US); C07D 295/185 (2013.01 - CN EP RU US); C07D 401/04 (2013.01 - CN EP RU US); C07D 401/12 (2013.01 - EP RU US); C07D 401/14 (2013.01 - EP RU US); C07D 403/04 (2013.01 - CN EP RU US); C07D 413/04 (2013.01 - CN EP RU US); C07D 417/04 (2013.01 - CN EP RU US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2015048662 A2 20150402; WO 2015048662 A3 20150507; AU 2014324595 A1 20160407; AU 2014324595 B2 20181220; CA 2925624 A1 20150402; CA 2925624 C 20210615; CN 104341388 A 20150211; CN 104341388 B 20170322; CY 1123388 T1 20211231; EP 3052476 A2 20160810; EP 3052476 A4 20170329; EP 3052476 B1 20200715; HK 1207063 A1 20160122; JP 2016531893 A 20161013; JP 6615752 B2 20191204; KR 102272792 B1 20210705; KR 20160058188 A 20160524; MX 2016004030 A 20161026; PL 3052476 T3 20210111; RS 60934 B1 20201130; RU 2016115803 A 20171109; RU 2016115803 A3 20180516; RU 2677884 C2 20190122; SG 11201602070T A 20160428; SI 3052476 T1 20201231; US 10301297 B2 20190528; US 11345695 B2 20220531; US 11840513 B2 20231212; US 2016237075 A1 20160818; US 2018222897 A1 20180809; US 2019276446 A1 20190912; US 2022298153 A1 20220922; US 2024101545 A1 20240328; US 9951056 B2 20180424
DOCDB simple family (application)
US 2014058084 W 20140929; AU 2014324595 A 20140929; CA 2925624 A 20140929; CN 201410519430 A 20140929; CY 201100914 T 20200929; EP 14848083 A 20140929; HK 15107557 A 20150806; JP 2016519913 A 20140929; KR 20167011580 A 20140929; MX 2016004030 A 20140929; PL 14848083 T 20140929; RS P20201182 A 20140929; RU 2016115803 A 20140929; SG 11201602070T A 20140929; SI 201431676 T 20140929; US 201415025654 A 20140929; US 201815942772 A 20180402; US 201916421197 A 20190523; US 202217804012 A 20220525; US 202318496692 A 20231027