Global Patent Index - EP 3058103 A4

EP 3058103 A4 20170517 - DETECTING AND MONITORING MUTATIONS IN HISTIOCYTOSIS

Title (en)

DETECTING AND MONITORING MUTATIONS IN HISTIOCYTOSIS

Title (de)

DETEKTION UND ÜBERWACHUNG VON MUTATIONEN IN DER HISTIOZYTOSE

Title (fr)

DÉTECTION ET SURVEILLANCE DE MUTATIONS D'HISTIOCYTOSE

Publication

EP 3058103 A4 20170517 (EN)

Application

EP 14853756 A 20141018

Priority

  • US 201361893218 P 20131019
  • US 201461977611 P 20140409
  • US 201462006261 P 20140601
  • US 201462040366 P 20140821
  • US 2014061281 W 20141018

Abstract (en)

[origin: WO2015058175A2] Provided is methods of detecting a mutation in a histiocytosis patient. Also provided is methods of selecting and/or applying treatment or therapy for a histiocytosis patient. Further provided is a method of treating a patient having a histiocytosis.

IPC 8 full level

C12Q 1/68 (2006.01)

CPC (source: EP)

C12Q 1/6883 (2013.01); C12Q 1/6886 (2013.01); C12Q 2600/118 (2013.01); C12Q 2600/156 (2013.01)

Citation (search report)

  • [I] WO 2008106453 A2 20080904 - WAYNE JOHN CANCER INST [US], et al
  • [ID] TAKESHI SATOH ET AL: "B-RAF Mutant Alleles Associated with Langerhans Cell Histiocytosis, a Granulomatous Pediatric Disease", PLOS ONE, vol. 7, no. 4, 10 April 2012 (2012-04-10), pages e33891, XP055362288, DOI: 10.1371/journal.pone.0033891
  • [ID] DIAMOND ELI ET AL.,: "Detection of an NRAS mutation in Erdheim-Chester disease", BLOOD, 8 August 2013 (2013-08-08), United States, pages 1089, XP055362342, Retrieved from the Internet <URL:http://www.bloodjournal.org/content/bloodjournal/122/6/1089.full.pdf>
  • [ID] J. HAROCHE ET AL: "High prevalence of BRAF V600E mutations in Erdheim-Chester disease but not in other non-Langerhans cell histiocytoses", BLOOD, vol. 120, no. 13, 9 August 2012 (2012-08-09), & 53RD ANNUAL MEETING AND EXPOSITION OF THE AMERICAN-SOCIETY-OF-HEMATOLOGY (ASH); SAN DIEGO, CA, USA; DECEMBER 10 -13, 2011, pages 2700 - 2703, XP055362341, ISSN: 0006-4971, DOI: 10.1182/blood-2012-05-430140
  • [I] THIERRY LECOMTE ET AL: "Detection of free-circulating tumor-associated DNA in plasma of colorectal cancer patients and its association with prognosis", INTERNATIONAL JOURNAL OF CANCER, vol. 100, no. 5, 10 August 2002 (2002-08-10), pages 542 - 548, XP055071717, ISSN: 0020-7136, DOI: 10.1002/ijc.10526
  • [ID] G. BADALIAN-VERY ET AL: "Recurrent BRAF mutations in Langerhans cell histiocytosis", BLOOD, vol. 116, no. 11, 16 September 2010 (2010-09-16), pages 1919 - 1923, XP055027891, ISSN: 0006-4971, DOI: 10.1182/blood-2010-04-279083
  • [IP] ALAIN R THIERRY ET AL: "Clinical validation of the detection of KRAS and BRAF mutations from circulating tumor DNA", vol. 20, no. 4, 1 April 2014 (2014-04-01), pages 430 - 435, XP002730498, ISSN: 1078-8956, Retrieved from the Internet <URL:http://www.nature.com/nm/journal/v20/n4/full/nm.3511.html> [retrieved on 20140323], DOI: 10.1038/NM.3511
  • [IDP] FILIP JANKU ET AL: "BRAF V600E mutations in urine and plasma cell-free DNA from patients with Erdheim-Chester disease", ONCOTARGET, vol. 5, no. 11, 13 May 2014 (2014-05-13), United States, pages 3607 - 3610, XP055153092, DOI: 10.18632/oncotarget.1964
  • See references of WO 2015058175A2

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2015058175 A2 20150423; WO 2015058175 A3 20150625; EP 3058103 A2 20160824; EP 3058103 A4 20170517; HK 1222206 A1 20170623; IL 244733 A0 20160421

DOCDB simple family (application)

US 2014061281 W 20141018; EP 14853756 A 20141018; HK 16110254 A 20160829; IL 24473316 A 20160322