EP 3065549 A4 20170524 - METHODS FOR INHIBITING TIE2 KINASE USEFUL IN THE TREATMENT OF CANCER
Title (en)
METHODS FOR INHIBITING TIE2 KINASE USEFUL IN THE TREATMENT OF CANCER
Title (de)
VERFAHREN ZUR HEMMUNG VON TIE2-KINASE ZUR BEHANDLUNG VON KREBS
Title (fr)
MÉTHODES D'INHIBITION DE LA KINASE TIE2 UTILES DANS LE TRAITEMENT DU CANCER
Publication
Application
Priority
US 2013069005 W 20131107
Abstract (en)
[origin: WO2015069266A1] The present invention relates to methods of inhibiting TIE2 kinase useful in the treatment of tumor growth, invasiveness, intravasation, dissemination, metastasis, and immunosuppression. Specifically, the invention relates to methods of using 1-(3-tert-butyl-1-(quinolin-6-yl)-1Hpyrazol- 5-yl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea and salts thereof of Formula I.
IPC 8 full level
A61K 31/4709 (2006.01); A61K 31/337 (2006.01); A61K 31/357 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01)
CPC (source: AU EP KR)
A61K 9/0019 (2013.01 - AU KR); A61K 9/0053 (2013.01 - AU); A61K 9/10 (2013.01 - AU KR); A61K 31/337 (2013.01 - AU EP KR); A61K 31/357 (2013.01 - AU EP KR); A61K 31/4709 (2013.01 - AU EP); A61K 31/4725 (2013.01 - KR); A61K 45/06 (2013.01 - EP KR); A61P 35/00 (2017.12 - AU EP); A61P 35/02 (2017.12 - EP); A61P 35/04 (2017.12 - AU EP); A61P 43/00 (2017.12 - EP); A61K 2300/00 (2013.01 - AU KR)
Citation (search report)
- [XYI] BRYAN D SMITH ET AL: "Abstract B78: Rebastinib, a small molecule TIE2 kinase inhibitor, prevents primary tumor growth and lung metastasis in the PyMT breast cancer model", February 2013 (2013-02-01), XP002769061, Retrieved from the Internet <URL:http://cancerres.aacrjournals.org/content/73/3_Supplement/B78> [retrieved on 20170410]
- [Y] JAVIER CORTES ET AL: "Eribulin monotherapy versus treatment of physician's choice in patients with metastatic breast cancer (EMBRACE): a phase 3 open-label randomised study", THE LANCET, vol. 377, no. 9769, 1 March 2011 (2011-03-01), pages 914 - 923, XP055030961, ISSN: 0140-6736, DOI: 10.1016/S0140-6736(11)60070-6
- See references of WO 2015069266A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2015069266 A1 20150514; AU 2013404949 A1 20160526; AU 2013404949 B2 20181018; AU 2019200261 A1 20190131; AU 2021200113 A1 20210304; CA 2929715 A1 20150514; CN 105873440 A 20160817; CN 105873440 B 20180601; CN 108464981 A 20180831; CN 108464981 B 20220624; EP 3065549 A1 20160914; EP 3065549 A4 20170524; JP 2017500371 A 20170105; JP 6568093 B2 20190828; KR 20160070188 A 20160617; KR 20210063475 A 20210601
DOCDB simple family (application)
US 2013069005 W 20131107; AU 2013404949 A 20131107; AU 2019200261 A 20190115; AU 2021200113 A 20210110; CA 2929715 A 20131107; CN 201380081931 A 20131107; CN 201810436668 A 20131107; EP 13896951 A 20131107; JP 2016552405 A 20131107; KR 20167014649 A 20131107; KR 20217015635 A 20131107