EP 3068930 A2 20160921 - BIOMARKER FOR MELK ACTIVITY AND METHODS OF USING SAME
Title (en)
BIOMARKER FOR MELK ACTIVITY AND METHODS OF USING SAME
Title (de)
BIOMARKER FÜR MELKAKTIVITÄT UND VERFAHREN ZUR VERWENDUNG DAVON
Title (fr)
BIOMARQUEUR DE L'ACTIVITÉ DE MELK ET SES PROCÉDÉS D'UTILISATION
Publication
Application
Priority
- US 201361902877 P 20131112
- US 201461954046 P 20140317
- US 2014065173 W 20141112
Abstract (en)
[origin: WO2015073509A2] The methods of the present invention, relate to the surprising determination that the level of phosphorylation of position 406 (e.g., a serine residue.) of human eukaryotic initiation factor 4B (cIF4B), or a corresponding phosphorylatafale amino acid of an ortholog thereof, serves as a bhiraarker for MELK enzymatic (e.g., kinase) and/or oncogenic activity. The methods of the present invention further ceiate to the surprising determination that the level of phosphorylation of position 3 (e.g., a threonine residue) and/or position 10 (e.g., a serine residue) and/or position 11 (e.g., a threonine residue) of human Historic M3, or a corresponding phosphorylatable amino acid of an ortholog thereof, also serves as a biomarker for MELK enzymatic (e.g., kinase) and/or oncogenic activity.
IPC 8 full level
C40B 30/08 (2006.01); C12N 9/12 (2006.01); C40B 20/00 (2006.01)
CPC (source: EP)
A61K 31/7088 (2013.01); C12Q 1/6886 (2013.01); G01N 33/5748 (2013.01); G01N 2333/912 (2013.01); G01N 2500/02 (2013.01)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2015073509 A2 20150521; WO 2015073509 A3 20160114; WO 2015073509 A8 20160526; AU 2014348780 A1 20160602; AU 2014348780 A8 20160630; AU 2014348780 B2 20181213; CA 2928464 A1 20150521; CN 106232878 A 20161214; EP 3068930 A2 20160921; EP 3068930 A4 20171004
DOCDB simple family (application)
US 2014065173 W 20141112; AU 2014348780 A 20141112; CA 2928464 A 20141112; CN 201480072848 A 20141112; EP 14862279 A 20141112