Global Patent Index - EP 3074514 A2

EP 3074514 A2 20161005 - ENZYMES FUNCTIONAL PROBES

Title (en)

ENZYMES FUNCTIONAL PROBES

Title (de)

FUNKTIONELLE ENZYMSONDEN

Title (fr)

SONDES FONCTIONNELLES ENZYMATIQUES

Publication

EP 3074514 A2 20161005 (EN)

Application

EP 14809958 A 20141128

Priority

  • GB 201320994 A 20131128
  • GB 201401001 A 20140121
  • GB 2014053549 W 20141128

Abstract (en)

[origin: WO2015079259A2] A method of selectively inhibiting a bromodomain in the presence of other bromodomains comprising introducing a functionally silent mutation into the bromodomain in the presence of other wild type bromodomains and selectively inhibiting the mutated bromodomain.

IPC 8 full level

C12N 15/10 (2006.01)

CPC (source: EP US)

A61K 31/5517 (2013.01 - EP US); C07D 487/04 (2013.01 - EP US); C12N 15/102 (2013.01 - EP US); G01N 33/6803 (2013.01 - US); G01N 2500/04 (2013.01 - US)

Citation (search report)

See references of WO 2015079259A2

Citation (examination)

  • EP 2585465 A1 20130501 - GLAXOSMITHKLINE LLC [US]
  • CHUNG CHUN-WA ET AL: "Discovery and characterization of small molecule inhibitors of the BET family bromodomains", vol. 54, no. 11, pages 3827 - 3838, XP008164769, ISSN: 0022-2623, Retrieved from the Internet <URL:http://pubs.acs.org/journals/jmcmar/index.html> [retrieved on 20110428], DOI: 10.1021/JM200108T
  • JEAN-MARC GARNIER ET AL: "BET bromodomain inhibitors: a patent review", EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 24, no. 2, 1 February 2014 (2014-02-01), pages 185 - 199, XP055121821, ISSN: 1354-3776, DOI: 10.1517/13543776.2014.859244
  • CHUN-WA CHUNG ET AL: "Bromodomains: a new target class for small molecule drug discovery", DRUG DISCOVERY TODAY: THERAPEUTIC STRATEGIES, vol. 9, no. 2-3, 1 September 2012 (2012-09-01), pages e111 - e120, XP055205493, ISSN: 1740-6773, DOI: 10.1016/j.ddstr.2011.12.002

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

DOCDB simple family (publication)

WO 2015079259 A2 20150604; WO 2015079259 A3 20150827; EP 3074514 A2 20161005; GB 201320994 D0 20140115; GB 201401001 D0 20140305; US 2017122958 A1 20170504

DOCDB simple family (application)

GB 2014053549 W 20141128; EP 14809958 A 20141128; GB 201320994 A 20131128; GB 201401001 A 20140121; US 201415039350 A 20141128