EP 3079698 A1 20161019 - COMBINATIONS OF TRAMETINIB, PANITUMUMAB AND DABRAFENIB FOR THE TREATMENT OF CANCER
Title (en)
COMBINATIONS OF TRAMETINIB, PANITUMUMAB AND DABRAFENIB FOR THE TREATMENT OF CANCER
Title (de)
KOMBINATIONEN AUS TRAMETINIB, PANITUMUMAB UND DABRAFENIB ZUR BEHANDLUNG VON KREBS
Title (fr)
COMBINAISONS DE TRAMÉTINIB, PANITUMUMAB ET DABRAFÉNIB POUR LE TRAITEMENT DU CANCER
Publication
Application
Priority
- US 201361915041 P 20131212
- US 201462004579 P 20140529
- IB 2014066814 W 20141211
Abstract (en)
[origin: WO2015087279A1] A novel combination comprising a B-Raf inhibitor, particularly N-{3-[5-(2- Amino-4-pyrimidinyl)-2-(1, 1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6- difluorobenzenesulfonamide or a pharmaceutically acceptable salt thereof, and/or the MEK inhibitor N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)6,8-dimethyl;- 2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, and panitumumab (Vectibix); pharmaceutical compositions comprising the same and methods of using such combinations and compositions in the treatment of conditions in which the inhibition of MEK and/or B-Raf and/or EGFR is beneficial, eg. cancer.
IPC 8 full level
A61K 31/506 (2006.01); A61K 31/519 (2006.01); A61K 39/395 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01); A61P 35/04 (2006.01)
CPC (source: EP KR US)
A61K 9/0019 (2013.01 - KR US); A61K 31/506 (2013.01 - EP KR US); A61K 31/519 (2013.01 - EP KR US); A61K 39/3955 (2013.01 - EP KR US); A61P 35/00 (2017.12 - EP); A61P 35/02 (2017.12 - EP); A61P 35/04 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07K 16/2863 (2013.01 - EP KR US); A61K 2039/505 (2013.01 - US); A61K 2039/54 (2013.01 - EP KR US); A61K 2039/545 (2013.01 - EP KR US); A61K 2300/00 (2013.01 - KR); C07K 2317/21 (2013.01 - EP KR US)
Citation (search report)
See references of WO 2015087279A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2015087279 A1 20150618; AU 2014362995 A1 20160526; BR 112016011222 A2 20170919; CA 2933311 A1 20150618; CN 106029074 A 20161012; EP 3079698 A1 20161019; JP 2017500307 A 20170105; KR 20160088884 A 20160726; MX 2016007653 A 20161013; US 2016367662 A1 20161222
DOCDB simple family (application)
IB 2014066814 W 20141211; AU 2014362995 A 20141211; BR 112016011222 A 20141211; CA 2933311 A 20141211; CN 201480075171 A 20141211; EP 14819083 A 20141211; JP 2016538556 A 20141211; KR 20167015238 A 20141211; MX 2016007653 A 20141211; US 201415100795 A 20141211