EP 3080114 B1 20191002 - FUSED TRICYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY
Title (en)
FUSED TRICYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY
Title (de)
KONDENSIERTE TRICYCLISCHE IMIDAZOLENDERIVATE ALS MODULATOREN DER TNF-AKTIVITÄT
Title (fr)
DÉRIVÉS D'IMIDAZOLE FUSIONNES TRICYCLIQUES UTILISABLES EN TANT QUE MODULATEURS DE L'ACTIVITÉ TNF
Publication
Application
Priority
- GB 201321730 A 20131209
- EP 2014076886 W 20141208
Abstract (en)
[origin: WO2015086527A1] A series of substituted fused tricyclic imidazole derivatives, in particular dihydro- 1H-pyrano[4',3':4,5]imidazo[1,2-a]pyridine, 1,2,3,4-tetrahydroimidazo[1,2-a:5,4- c']dipyridine, dihydro-1H-pyrano[3',4':4,5]imidazo[1,2-a]pyridine and tetrahydro-6H- cyclohepta[4,5]imidazo[1,2-a]pyridine, and analogues thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
IPC 8 full level
C07D 471/04 (2006.01); A61K 31/437 (2006.01); A61K 31/4375 (2006.01); C07D 471/14 (2006.01); C07D 491/14 (2006.01)
CPC (source: EP RU US)
A61K 31/437 (2013.01 - RU); A61K 31/506 (2013.01 - RU); A61P 1/06 (2017.12 - EP RU); A61P 3/00 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 17/06 (2017.12 - EP RU); A61P 19/02 (2017.12 - EP RU); A61P 25/00 (2017.12 - EP); A61P 25/04 (2017.12 - EP); A61P 27/02 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 37/06 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 471/04 (2013.01 - EP RU US); C07D 471/14 (2013.01 - EP RU US); C07D 491/14 (2013.01 - EP US); C07D 491/147 (2013.01 - EP RU US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2015086527 A1 20150618; BR 112016013012 A2 20170808; CA 2932057 A1 20150618; CA 2932057 C 20220719; CN 105814047 A 20160727; CN 105814047 B 20181019; EP 3080114 A1 20161019; EP 3080114 B1 20191002; ES 2759253 T3 20200508; GB 201321730 D0 20140122; JP 2016539958 A 20161222; JP 6571653 B2 20190904; RU 2016127230 A 20180123; RU 2700004 C1 20190912; RU 2700004 C9 20191025; US 2016304530 A1 20161020; US 9890174 B2 20180213
DOCDB simple family (application)
EP 2014076886 W 20141208; BR 112016013012 A 20141208; CA 2932057 A 20141208; CN 201480067051 A 20141208; EP 14808659 A 20141208; ES 14808659 T 20141208; GB 201321730 A 20131209; JP 2016537430 A 20141208; RU 2016127230 A 20141208; US 201415101798 A 20141208