EP 3083591 B1 20180103 - N1-(3,3,3-TRIFLUORO-2-HYDROXO-2-METHYLPROPIONYL)-PIPERIDINE DERIVATIVES AS INHIBITORS OF PYRUVATE DEHYDROGENASE KINASE
Title (en)
N1-(3,3,3-TRIFLUORO-2-HYDROXO-2-METHYLPROPIONYL)-PIPERIDINE DERIVATIVES AS INHIBITORS OF PYRUVATE DEHYDROGENASE KINASE
Title (de)
N1-(3,3,3-TRIFLUOR-2-HYDROXO-2-METHYLPROPIONYL)-PIPERIDIN-DERIVATE ALS INHIBITOREN DER PYRUVATDEHYDROGENASEKINASE
Title (fr)
DÉRIVÉS N1-(3,3,3-TRIFLUORO-2-HYDROXO-2-MÉTHYLPROPIONYL)-PIPÉRIDINE EN TANT QU'INHIBITEURS DE PYRUVATE DÉSHYDROGÉNASE KINASE
Publication
Application
Priority
- EP 13005865 A 20131217
- EP 2014003086 W 20141119
- EP 14799674 A 20141119
Abstract (en)
[origin: WO2015090496A1] Compounds of the formula (I) in which R, R1 and R3 have the meanings indicated in Claim 1, are inhibitors of pyruvate dehydrogenase kinase (PDHK), and can be employed, inter alia, for the treatment of diseases such as cancer.
IPC 8 full level
C07D 401/14 (2006.01); A61K 31/454 (2006.01); A61P 3/00 (2006.01); A61P 35/00 (2006.01); C07D 401/04 (2006.01); C07D 405/14 (2006.01); C07D 413/04 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01)
CPC (source: EP KR US)
A61K 31/454 (2013.01 - KR US); A61K 31/4545 (2013.01 - US); A61K 31/501 (2013.01 - US); A61K 31/506 (2013.01 - US); A61K 45/06 (2013.01 - KR); A61P 3/00 (2017.12 - EP); A61P 3/06 (2017.12 - EP); A61P 3/10 (2017.12 - EP); A61P 5/50 (2017.12 - EP); A61P 7/00 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 9/04 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 21/00 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 401/04 (2013.01 - EP KR US); C07D 401/14 (2013.01 - EP KR US); C07D 405/14 (2013.01 - EP KR US); C07D 413/04 (2013.01 - EP KR US); C07D 413/14 (2013.01 - EP KR US); C07D 417/14 (2013.01 - EP KR US); A61K 2300/00 (2013.01 - KR)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2015090496 A1 20150625; AU 2014365904 A1 20160728; AU 2014365904 B2 20190328; CA 2933927 A1 20150625; CA 2933927 C 20211116; CN 105814037 A 20160727; CN 105814037 B 20181130; EP 3083591 A1 20161026; EP 3083591 B1 20180103; ES 2665148 T3 20180424; IL 246298 A0 20160802; IL 246298 B 20181031; JP 2016540807 A 20161228; JP 6527520 B2 20190605; KR 102374178 B1 20220314; KR 20160098475 A 20160818; MX 2016007810 A 20160907; NZ 721726 A 20210730; SG 11201604940V A 20160728; TW 201605824 A 20160216; US 2016311798 A1 20161027; US 9751861 B2 20170905; ZA 201604932 B 20190424
DOCDB simple family (application)
EP 2014003086 W 20141119; AU 2014365904 A 20141119; CA 2933927 A 20141119; CN 201480069392 A 20141119; EP 14799674 A 20141119; ES 14799674 T 20141119; IL 24629816 A 20160616; JP 2016540613 A 20141119; KR 20167019303 A 20141119; MX 2016007810 A 20141119; NZ 72172614 A 20141119; SG 11201604940V A 20141119; TW 103143948 A 20141216; US 201415105154 A 20141119; ZA 201604932 A 20160715