EP 3087095 A1 20161102 - FCRN ANTAGONISTS AND METHODS OF USE
Title (en)
FCRN ANTAGONISTS AND METHODS OF USE
Title (de)
FCRN-ANTAGONISTEN UND VERFAHREN ZUR VERWENDUNG
Title (fr)
ANTAGONISTES DU FCRN ET PROCÉDÉS D'UTILISATION
Publication
Application
Priority
- US 201361920547 P 20131224
- US 2014072087 W 20141223
Abstract (en)
[origin: WO2015100299A1] Provided are novel FcRn antagonist compositions comprising a variant Fc region that binds specifically to FcRn with increased affinity and reduced pH dependence relative to the native Fc region. Also provided are FcRn antagonists with enhanced CD 16 binding affinity. Also provided are methods of treating antibody-mediated disorders (e.g. autoimmune diseases) using the these FcRn antagonist compositions, nucleic acids encoding the FcRn antagonist compositions, recombinant expression vectors and host cells for making the FcRn antagonist compositions, and pharmaceutical compositions comprising the FcRn antagonist compositions.
IPC 8 full level
C07K 16/00 (2006.01); A61K 38/00 (2006.01); A61K 38/17 (2006.01)
CPC (source: EA EP IL KR US)
A61K 38/00 (2013.01 - IL); A61K 38/1709 (2013.01 - EA EP IL US); A61K 45/06 (2013.01 - EA EP IL US); A61P 1/02 (2018.01 - EA EP IL); A61P 1/04 (2018.01 - EA EP IL); A61P 1/16 (2018.01 - EA EP IL); A61P 3/10 (2018.01 - EA EP IL); A61P 5/14 (2018.01 - EA EP IL); A61P 7/00 (2018.01 - EA EP IL); A61P 7/04 (2018.01 - EA EP IL); A61P 7/06 (2018.01 - EA EP IL); A61P 9/00 (2018.01 - EA EP IL); A61P 15/00 (2018.01 - EA EP IL); A61P 17/00 (2018.01 - EA EP IL); A61P 17/02 (2018.01 - EA EP IL); A61P 17/04 (2018.01 - EA EP IL); A61P 17/14 (2018.01 - EA EP IL); A61P 19/00 (2018.01 - EA EP IL); A61P 19/02 (2018.01 - EA EP IL); A61P 19/04 (2018.01 - EA EP IL); A61P 21/00 (2018.01 - EA EP IL); A61P 21/02 (2018.01 - EA EP IL); A61P 25/00 (2018.01 - EA EP IL); A61P 25/08 (2018.01 - EA EP IL); A61P 25/28 (2018.01 - EA EP IL); A61P 27/02 (2018.01 - EA EP IL); A61P 29/00 (2018.01 - EA EP IL); A61P 35/00 (2018.01 - EA EP IL); A61P 37/00 (2018.01 - KR); A61P 37/06 (2018.01 - EA EP IL); C07K 14/4703 (2013.01 - EA IL US); C07K 16/00 (2013.01 - EA EP IL); C07K 16/283 (2013.01 - KR); A61K 38/00 (2013.01 - EA EP US); A61K 2039/505 (2013.01 - KR); C07K 2317/41 (2013.01 - EA EP IL US); C07K 2317/52 (2013.01 - EA EP IL KR US); C07K 2317/524 (2013.01 - EA EP IL US); C07K 2317/526 (2013.01 - EA EP IL US); C07K 2317/76 (2013.01 - KR); C07K 2317/94 (2013.01 - EA EP IL KR US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2015100299 A1 20150702; AU 2014369999 A1 20160707; AU 2014369999 B2 20191212; BR 112016014810 A2 20170919; BR 112016014810 B1 20231226; CA 2934644 A1 20150702; CA 2934644 C 20231121; CN 106103476 A 20161109; CN 106103476 B 20201127; CN 112142843 A 20201229; DK 3087095 T3 20191028; EA 035324 B1 20200528; EA 201691304 A1 20161031; EP 3087095 A1 20161102; EP 3087095 B1 20190807; EP 3626738 A1 20200325; ES 2742682 T3 20200217; FI C20230003 I1 20230119; FR 23C1004 I1 20230310; FR 23C1004 I2 20240105; HU E046822 T2 20200330; HU S2200048 I1 20221228; IL 246223 A0 20160731; IL 246223 B 20210630; JP 2017501725 A 20170119; JP 2019076103 A 20190523; JP 6554473 B2 20190731; KR 102452173 B1 20221017; KR 20160111937 A 20160927; KR 20220152546 A 20221116; KR 20240033084 A 20240312; LT 3087095 T 20190910; LT PA2022014 I1 20221212; MX 2016008399 A 20161215; MX 368804 B 20191017; NL 301203 I1 20221109; NL 301203 I2 20230524; NZ 722055 A 20200228; PL 3087095 T3 20200331; PT 3087095 T 20191009; SG 10202009832X A 20201127; SG 11201605203U A 20160728; US 10316073 B2 20190611; US 11505585 B2 20221122; US 2015218239 A1 20150806; US 2018179258 A1 20180628; US 2022275035 A1 20220901
DOCDB simple family (application)
US 2014072087 W 20141223; AU 2014369999 A 20141223; BR 112016014810 A 20141223; CA 2934644 A 20141223; CN 201480070435 A 20141223; CN 202010983097 A 20141223; DK 14827372 T 20141223; EA 201691304 A 20141223; EP 14827372 A 20141223; EP 19189186 A 20141223; ES 14827372 T 20141223; FI C20230003 C 20230119; FR 23C1004 C 20230112; HU E14827372 A 20141223; HU S2200048 C 20221121; IL 24622316 A 20160614; JP 2016542697 A 20141223; JP 2019002272 A 20190110; KR 20167020339 A 20141223; KR 20227034365 A 20141223; KR 20247006088 A 20141223; LT 14827372 T 20141223; LT PA2022014 C 20221115; MX 2016008399 A 20141223; NL 301203 C 20221103; NZ 72205514 A 20141223; PL 14827372 T 20141223; PT 14827372 T 20141223; SG 10202009832X A 20141223; SG 11201605203U A 20141223; US 201414580771 A 20141223; US 201715821104 A 20171122; US 202217672346 A 20220215