EP 3098233 A1 20161130 - RETICULOCYTE GROWTH FACTOR, AND PREPARATION METHOD AND APPLICATION THEREOF
Title (en)
RETICULOCYTE GROWTH FACTOR, AND PREPARATION METHOD AND APPLICATION THEREOF
Title (de)
RETIKULOZYTENWACHSTUMSFAKTOR UND HERSTELLUNGSVERFAHREN UND ANWENDUNG DAVON
Title (fr)
FACTEUR DE CROISSANCE DES RÉTICULOCYTES, PROCÉDÉ DE PRÉPARATION ET APPLICATION ASSOCIÉS
Publication
Application
Priority
- CN 201410036118 A 20140124
- CN 2014071586 W 20140127
Abstract (en)
The present invention belongs to the field of medical biotechnology, and particular relates to a Reticulocyte Growth Factor (RGF) and a preparing method and application thereof. The factor is separated and purified from impurities of ± 1 -antitrypsin (from human plasma), and the fragment of a precursor of the antitrypsin is determined, and has very high function of promoting the generation of the reticulocyte of mice. Monoclonal antibody of EPO is not combined with the reticulocyte growth factor, which is labeled with I 125 , after the reticulocyte growth factor is combined with surface receptors of mouse bone marrow cells, the EPO cannot compete with the reticulocyte growth factor. The EPO and RGF are labeled with different fluorochromes, and it is proved that they have different receptors. The factor and EPO are injected into the mice or aplastic anemia mice, and an obvious synergistic effect for promoting the generation of the reticulocyte, red cell and leukocyte is generated. The reticulocyte growth factor can be used for preparing the medicine for treating severe anemia.
IPC 8 full level
C07K 14/505 (2006.01); A61K 38/19 (2006.01); A61P 7/00 (2006.01); C07K 1/20 (2006.01)
CPC (source: CN EP KR RU US)
A61K 38/18 (2013.01 - KR US); A61K 38/1816 (2013.01 - KR US); A61K 38/19 (2013.01 - RU); A61P 7/00 (2017.12 - EP); A61P 7/06 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07K 1/20 (2013.01 - RU); C07K 14/475 (2013.01 - CN KR US); C07K 14/505 (2013.01 - EP KR RU US); A61K 38/00 (2013.01 - CN EP US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
EP 3098233 A1 20161130; EP 3098233 A4 20170621; AU 2014379070 A1 20160512; AU 2018203565 A1 20180607; AU 2018203565 B2 20191114; CA 2930049 A1 20150730; CN 103804484 A 20140521; CN 103804484 B 20160316; HK 1226085 A1 20170922; JP 2017506221 A 20170302; JP 6434525 B2 20181205; KR 20160111909 A 20160927; NZ 719356 A 20171222; RU 2016133855 A 20180301; RU 2016133855 A3 20180301; RU 2703176 C2 20191015; US 2016326226 A1 20161110; WO 2015109604 A1 20150730
DOCDB simple family (application)
EP 14879409 A 20140127; AU 2014379070 A 20140127; AU 2018203565 A 20180521; CA 2930049 A 20140127; CN 2014071586 W 20140127; CN 201410036118 A 20140124; HK 16114515 A 20161221; JP 2016548248 A 20140127; KR 20167015392 A 20140127; NZ 71935614 A 20140127; RU 2016133855 A 20140127; US 201415036075 A 20140127