EP 3099790 A2 20161207 - COLISTIN SYNTHETASES AND CORRESPONDING GENE CLUSTER
Title (en)
COLISTIN SYNTHETASES AND CORRESPONDING GENE CLUSTER
Title (de)
COLISTIN-SYNTHETASEN UND ENTSPRECHENDES GENCLUSTER
Title (fr)
SYNTHETASES DE LA COLISTINE ET CLUSTER DE GENES CORRESPONDANTS
Publication
Application
Priority
- FR 1450641 A 20140127
- IB 2015050571 W 20150126
Abstract (en)
[origin: WO2015111013A2] Synthetase PmxA involved in the synthesis of polymyxin E, comprising four adenylation sites, characterised in that the second adenylation site has at least 90% identity with the peptide sequence SEQ ID NO 1: VTEAEKADLLGRFNDTTTEFPRGKTLIQLFEEQVERIPDAAAITLNEQE LTYRELNERVNRLARTLRSHGISKGRLVAILAERSIEMVVGMLAAHKAGAAYVPI DPEYPEERIRFLIEDSGGQVMLTQSRLRERLAGSDPVILLDDESFYHEDGTNLNTGI EATDLACVIYTSGTTGKPKGNPVSHRNIVRVVQNTNYIDITERDHVLQLSSYSF<u>DG</u> AT<u>F</u>DIFGALTNGARLVLVPYETLLEIGRLADLIQRERISVM<u>F</u>ITTAFFNILVDVNVD CLRDVRAI<u>L</u>F<u>G</u>GERVSVGHVRKALAHIGPGRLNH<u>V</u>YGPTEST<u>VY</u>TTYLPVDFVDE LAVTVPIGRPISNTTVYIVDSRNKLLPIGVAGELCVGGEGLVRGYNNRPELTAEKF VDNPFVPGERMYRTGDLAKWLPDGTIEYVGRTDDQVKIRGFRIELGEIEAQLQKV EGIRKTTVFARENASGEKQLCAYYEADCELPAAELKSVLSKELPAYMIPAYLIQLE RLPLTTNG<u>K</u>VDRRSLPAPEESLQPGGG, underlined amino acids DGFFLGVVYK being conserved and forming a specific binding pocket for a leucine, isoleucine or valine residue.
IPC 8 full level
C12N 9/00 (2006.01)
CPC (source: EP US)
A61P 31/04 (2017.12 - EP); C07K 7/62 (2013.01 - EP US); C12N 9/93 (2013.01 - EP US); C12N 15/52 (2013.01 - EP US); C12P 21/02 (2013.01 - EP US)
Citation (search report)
See references of WO 2015111013A2
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2015111013 A2 20150730; WO 2015111013 A3 20151223; CA 2944826 A1 20150730; EP 3099790 A2 20161207; FR 3016888 A1 20150731; FR 3016888 B1 20210122; JP 2017503528 A 20170202; JP 6637904 B2 20200129; US 10246697 B2 20190402; US 2016348088 A1 20161201
DOCDB simple family (application)
IB 2015050571 W 20150126; CA 2944826 A 20150126; EP 15704379 A 20150126; FR 1450641 A 20140127; JP 2016565583 A 20150126; US 201515113978 A 20150126