Global Patent Index - EP 3102206 A4

EP 3102206 A4 20170920 - COMBINATIONS OF IKK /TBK1 INHIBITORS WITH BETA ADRENERGIC AGONISTS OR SYMPATHETIC NERVOUS SYSTEM ACTIVATORS

Title (en)

COMBINATIONS OF IKK /TBK1 INHIBITORS WITH BETA ADRENERGIC AGONISTS OR SYMPATHETIC NERVOUS SYSTEM ACTIVATORS

Title (de)

KOMBINATIONEN VON IKK/TBK1-INHIBITOREN MIT BETA-ADRENERGISCHEN AGONISTEN ODER AKTIVATOREN DES SYMPATHISCHEN NERVENSYSTEMS

Title (fr)

COMBINAISONS D'INHIBITEURS DE IKK /TBK1 AVEC DES AGONISTES BÊTA-ADRÉNERGIQUES OU DES ACTIVATEURS DE SYSTÈME NERVEUX SYMPATHIQUE

Publication

EP 3102206 A4 20170920 (EN)

Application

EP 14881460 A 20140207

Priority

US 2014015387 W 20140207

Abstract (en)

[origin: WO2015119624A1] Provided herein are methods of treating obesity and obesity-related conditions comprising the administration of combinations of IKKε/TBK1 inhibitors with beta adrenergic agonists or sympathetic nervous system activators, and pharmaceutical compositions comprising such combinations. Obesity generates a state of chronic, low-grade inflammation in liver and adipose tissue accompanied by macrophage infiltration and the local secretion of inflammatory cytokines and chemokines that attenuate insulin action.

IPC 8 full level

A61K 31/436 (2006.01); A61K 31/137 (2006.01); A61K 31/36 (2006.01); A61K 31/4184 (2006.01); A61K 45/06 (2006.01); A61P 1/16 (2006.01); A61P 3/04 (2006.01); A61P 3/10 (2006.01)

CPC (source: EP)

A61K 31/137 (2013.01); A61K 31/36 (2013.01); A61K 31/4184 (2013.01); A61K 31/436 (2013.01); A61K 45/06 (2013.01); A61P 1/16 (2017.12); A61P 3/04 (2017.12); A61P 3/06 (2017.12); A61P 3/10 (2017.12); A61P 43/00 (2017.12)

C-Set (source: EP)

  1. A61K 31/436 + A61K 2300/00
  2. A61K 31/137 + A61K 2300/00
  3. A61K 31/4184 + A61K 2300/00
  4. A61K 31/36 + A61K 2300/00

Citation (search report)

  • [X] WO 2010139985 A1 20101209 - BIOCOPEA LTD [GB], et al
  • [XYI] JONATHAN MOWERS ET AL: "Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKK[epsilon] and TBK1", ELIFE, vol. 2, 24 December 2013 (2013-12-24), pages e01119 - 1, XP055219656, DOI: 10.7554/eLife.01119
  • [Y] J. G. KANG ET AL: "Randomized controlled trial to investigate the effects of a newly developed formulation of phentermine diffuse-controlled release for obesity", DIABETES, OBESITY AND METABOLISM, vol. 12, no. 10, 29 October 2010 (2010-10-29), pages 876 - 882, XP055337209, ISSN: 1462-8902, DOI: 10.1111/j.1463-1326.2010.01242.x
  • See references of WO 2015119624A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2015119624 A1 20150813; AU 2014381711 A1 20160818; CA 2938126 A1 20150813; CN 106132413 A 20161116; EP 3102206 A1 20161214; EP 3102206 A4 20170920; JP 2017507930 A 20170323

DOCDB simple family (application)

US 2014015387 W 20140207; AU 2014381711 A 20140207; CA 2938126 A 20140207; CN 201480077641 A 20140207; EP 14881460 A 20140207; JP 2016550219 A 20140207