EP 3104889 A4 20170726 - ACTIVATION OF INNATE IMMUNITY FOR ENHANCED NUCLEAR REPROGRAMMING OF SOMATIC CELLS WITH mRNA
Title (en)
ACTIVATION OF INNATE IMMUNITY FOR ENHANCED NUCLEAR REPROGRAMMING OF SOMATIC CELLS WITH mRNA
Title (de)
AKTIVIERUNG VON ANGEBORENER IMMUNITÄT ZUR ERWEITERTEN NUKLEAREN NEUPROGRAMMIERUNG VON SOMATISCHEN ZELLEN MIT MRNA
Title (fr)
ACTIVATION DE L'IMMUNITÉ INNÉE POUR AMÉLIORER LA REPROGRAMMATION NUCLÉAIRE DE CELLULES SOMATIQUES AVEC UN ARNM
Publication
Application
Priority
- US 201461937923 P 20140210
- US 2015014748 W 20150206
Abstract (en)
[origin: US2015225699A1] The nuclear reprogramming of somatic cells with mRNA encoding reprogramming factors is shown to be greatly accelerated by activation of innate immune responses in the somatic cell. Methods of activating innate immunity include activation of PKR, of toll-like receptors, e.g. TLR3, etc. In some embodiments the mRNA provides the activator of innate immunity.
IPC 8 full level
A61K 45/00 (2006.01); C12N 5/00 (2006.01); C12N 5/074 (2010.01); C12N 15/00 (2006.01)
CPC (source: EP US)
C12N 5/0696 (2013.01 - EP US); C12N 2501/04 (2013.01 - EP US); C12N 2501/60 (2013.01 - EP US); C12N 2501/602 (2013.01 - EP US); C12N 2501/603 (2013.01 - EP US); C12N 2501/604 (2013.01 - EP US); C12N 2501/606 (2013.01 - EP US); C12N 2501/608 (2013.01 - EP US); C12N 2501/90 (2013.01 - US); C12N 2501/998 (2013.01 - EP US); C12N 2506/09 (2013.01 - US); C12N 2506/28 (2013.01 - EP US)
Citation (search report)
- [X] US 2013189741 A1 20130725 - MEIS JUDITH [US], et al
- [Y] WO 2013109763 A2 20130725 - UNIV LELAND STANFORD JUNIOR [US]
- [Y] WO 2011071936 A2 20110616 - DAHL GARY [US], et al
- [Y] JIEUN LEE ET AL: "Activation of Innate Immunity Is Required for Efficient Nuclear Reprogramming", CELL, vol. 151, no. 3, 1 October 2012 (2012-10-01), pages 547 - 558, XP055077006, ISSN: 0092-8674, DOI: 10.1016/j.cell.2012.09.034
- See references of WO 2015120225A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
US 2015225699 A1 20150813; US 9738873 B2 20170822; EP 3104889 A1 20161221; EP 3104889 A4 20170726; EP 3104889 B1 20211013; EP 3991751 A1 20220504; ES 2895941 T3 20220223; US 10760061 B2 20200901; US 11884937 B2 20240130; US 2017204376 A1 20170720; US 2021130792 A1 20210506; WO 2015120225 A1 20150813
DOCDB simple family (application)
US 201514615955 A 20150206; EP 15745937 A 20150206; EP 21196906 A 20150206; ES 15745937 T 20150206; US 2015014748 W 20150206; US 201715479979 A 20170405; US 202016986071 A 20200805