EP 3107552 B1 20180328 - METHOD FOR IN SITU INHIBITION OF REGULATORY T CELLS
Title (en)
METHOD FOR IN SITU INHIBITION OF REGULATORY T CELLS
Title (de)
VERFAHREN ZUR IN-SITU-HEMMUNG VON REGULATORISCHEN T-ZELLEN
Title (fr)
PROCÉDÉ D'INHIBITION IN SITU DE CELLULES T RÉGULATRICES
Publication
Application
Priority
- DK PA201470088 A 20140221
- EP 2015053592 W 20150220
Abstract (en)
[origin: WO2015124715A1] The present invention pertains to engineered T-cells, method for their preparation and their use as medicament, particularly for immunotherapy. The engineered T-cells of the invention are designed to express both a Chimeric Antigen Receptor (CAR) directed against at least one antigen expressed at the surface of a malignant or infected cell, and a secreted inhibitor of regulatory T-cells (Treg). Preferably, such secreted inhibitor is a peptide inhibitor of forkhead/winged helix transcription factor 3 (FoxP3), a specific factor involved into the differentiation of T-cells into regulatory T-cells. The engineered T-cells of the invention direct theirimmune activity towards specific malignant or infected cells, while at the same time will prevent neighbouring regulatory T-cells from modulating the immune response. The invention opens the way to standard and affordable adoptive immunotherapy strategies, especially for treating or preventing cancer, and bacterial or viral infections.
IPC 8 full level
A61K 35/14 (2015.01); C07K 14/725 (2006.01); C12N 5/0783 (2010.01)
CPC (source: EP US)
A61K 35/17 (2013.01 - US); A61K 39/4611 (2023.05 - EP); A61K 39/4631 (2023.05 - EP); A61K 39/464412 (2023.05 - EP); A61P 31/12 (2018.01 - EP); A61P 35/00 (2018.01 - EP); A61P 35/02 (2018.01 - EP); C07K 14/4703 (2013.01 - EP US); C07K 14/7051 (2013.01 - EP US); C07K 14/7155 (2013.01 - US); C07K 16/2803 (2013.01 - US); C07K 16/2866 (2013.01 - US); C12N 5/0636 (2013.01 - EP US); C12N 5/0638 (2013.01 - EP US); C12N 9/16 (2013.01 - EP US); C07K 2317/622 (2013.01 - US); C07K 2319/74 (2013.01 - US); C12N 2501/60 (2013.01 - US); C12N 2510/00 (2013.01 - EP US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2015124715 A1 20150827; AU 2015220762 A1 20160728; AU 2015220762 B2 20190502; CA 2939711 A1 20150827; CA 2939711 C 20200929; EP 3107552 A1 20161228; EP 3107552 B1 20180328; JP 2017506894 A 20170316; JP 6665102 B2 20200313; US 10196608 B2 20190205; US 2017067022 A1 20170309; US 2018208896 A1 20180726
DOCDB simple family (application)
EP 2015053592 W 20150220; AU 2015220762 A 20150220; CA 2939711 A 20150220; EP 15706446 A 20150220; JP 2016553321 A 20150220; US 201515120060 A 20150220; US 201815923771 A 20180316