EP 3107562 B1 20190918 - P97-IDS FUSION PROTEINS
Title (en)
P97-IDS FUSION PROTEINS
Title (de)
P97-IDS-FUSIONSPROTEINE
Title (fr)
PROTÉINES DE FUSION P97-IDS
Publication
Application
Priority
- US 201461941896 P 20140219
- US 2015015662 W 20150212
Abstract (en)
[origin: WO2015126729A1] Provided are fusion proteins between p97 (melanotransferrin) and iduronate-2-sulfatase (IDS), and related compositions and methods of use thereof, for instance, to facilitate delivery of IDS across the blood-brain barrier (BBB) and/or improve its tissue penetration in CNS and/or peripheral tissues, and thereby treat and/or diagnose Hunter Syndrome (Mucopolysaccharidosis type II; MPS II) and related lysosomal storage disorders, including those having a central nervous system (CNS) component.
IPC 8 full level
A61K 38/00 (2006.01); A61K 9/00 (2006.01); A61K 38/40 (2006.01); A61K 38/46 (2006.01); C07K 14/705 (2006.01); C12N 9/14 (2006.01); C12N 9/16 (2006.01)
CPC (source: EP IL US)
A61K 9/0019 (2013.01 - IL); A61K 38/00 (2013.01 - IL); A61K 38/40 (2013.01 - EP IL US); A61K 38/465 (2013.01 - EP IL US); A61P 3/00 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07K 14/70596 (2013.01 - EP IL US); C12N 9/14 (2013.01 - EP IL US); C12N 9/16 (2013.01 - EP IL US); C12Y 301/06013 (2013.01 - EP IL US); C12Y 306/04006 (2013.01 - EP IL US); A61K 9/0019 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US); C07K 2319/00 (2013.01 - EP IL US); C07K 2319/21 (2013.01 - EP IL US); C07K 2319/43 (2013.01 - IL US); C07K 2319/50 (2013.01 - IL US)
Citation (examination)
WO 2014160438 A1 20141002 - BIOASIS TECHNOLOGIES INC [CA]
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2015126729 A1 20150827; AU 2015219339 A1 20160707; AU 2015219339 B2 20200305; BR 112016018721 A2 20171010; CA 2935805 A1 20150827; CA 2935805 C 20230711; DK 3107562 T3 20191216; EP 3107562 A1 20161228; EP 3107562 B1 20190918; ES 2762672 T3 20200525; HK 1232136 A1 20180105; IL 246355 A0 20160831; IL 246355 B 20200630; JP 2017506886 A 20170316; JP 2020059710 A 20200416; JP 6605482 B2 20191113; JP 6930756 B2 20210901; JP 6930756 B6 20211020; US 10392605 B2 20190827; US 11124781 B2 20210921; US 2017204386 A1 20170720; US 2020270590 A1 20200827
DOCDB simple family (application)
US 2015015662 W 20150212; AU 2015219339 A 20150212; BR 112016018721 A 20150212; CA 2935805 A 20150212; DK 15708375 T 20150212; EP 15708375 A 20150212; ES 15708375 T 20150212; HK 17105773 A 20170612; IL 24635516 A 20160620; JP 2016548219 A 20150212; JP 2019189551 A 20191016; US 201515119293 A 20150212; US 201916449359 A 20190622