Global Patent Index - EP 3116996 A4

EP 3116996 A4 20180110 - TREATMENT OF RESISTANT LESIONS

Title (en)

TREATMENT OF RESISTANT LESIONS

Title (de)

BEHANDLUNG VON RESISTENTEN LÄSIONEN

Title (fr)

TRAITEMENT DE LÉSIONS RÉSISTANTES

Publication

EP 3116996 A4 20180110 (EN)

Application

EP 15760904 A 20150316

Priority

  • US 201461953604 P 20140314
  • US 201461953608 P 20140314
  • US 2015020786 W 20150316

Abstract (en)

[origin: WO2015139047A2] Connexin protein modulation methods and compositions are provided for the healing of resistant lesions, including lesions on subjects with multiple venous leg ulcers or multiple diabetic foot ulcers, and other responder subjects. Also provided are kits and articles of manufacture comprising a connexin protein modulating agent, for example, a connexin 43 modulating agent for use in the healing of resistant lesions.

IPC 8 full level

C12N 15/11 (2006.01); A61K 31/7088 (2006.01); A61K 38/00 (2006.01); C07H 21/04 (2006.01)

CPC (source: EP)

A61K 31/7088 (2013.01); C12N 15/1138 (2013.01); C12N 2310/11 (2013.01); C12N 2310/14 (2013.01)

Citation (search report)

  • [XI] WO 2008073479 A2 20080619 - CODA THERAPEUTICS INC [US], et al
  • [XPA] WO 2014145342 A2 20140918 - CODA THERAPEUTICS INC [US]
  • [A] WO 2009075881 A2 20090618 - CODA THERAPEUTICS INC [US], et al
  • [A] ARIADNA MENDOZA-NARANJO ET AL: "Overexpression of the gap junction protein Cx43 as found in diabetic foot ulcers can retard fibroblast migration", CELL BIOLOGY INTERNATIONAL., vol. 36, no. 7, 8 June 2012 (2012-06-08), GB, pages 661 - 667, XP055402070, ISSN: 1065-6995, DOI: 10.1042/CBI20110628
  • [A] QIU C ET AL: "Targeting Connexin43 Expression Accelerates the Rate of Wound Repair", CURRENT BIO, CURRENT SCIENCE, GB, vol. 13, no. 19, 30 September 2003 (2003-09-30), pages 1697 - 1703, XP004545249, ISSN: 0960-9822, DOI: 10.1016/J.CUB.2003.09.007
  • [A] JOHANNA M BRANDNER ET AL: "See related Commentary on page ix Connexins 26, 30, and 43: Differences Among Spontaneous, Chronic, and Accelerated Human Wound Healing", 1 May 2004 (2004-05-01), XP055402063, Retrieved from the Internet <URL:http://ac.els-cdn.com/S0022202X15308010/1-s2.0-S0022202X15308010-main.pdf?_tid=93f36308-8cba-11e7-9b03-00000aab0f26&acdnat=1504012043_813c67923de0c385013b5614ac11fb7b> [retrieved on 20170829]
  • [A] WANG CHINHUI MARY ET AL: "Abnormal connexin expression underlies delayed wound healing in diabetic skin", DIABETES, AMERICAN DIABETES ASSOCIATION, US, vol. 56, no. 11, 1 November 2007 (2007-11-01), pages 2809 - 2817, XP002529575, ISSN: 0012-1797, [retrieved on 20070823], DOI: 10.2337/DB07-0613
  • [A] MORI RYOICHI ET AL: "Acute downregulation of connexin43 at wound sites leads to a reduced inflammatory response, enhanced keratinocyte proliferation and wound fibroblast migration", JOURNAL OF CELL SCIENCE, CAMBRIDGE UNIVERSITY PRESS, LONDON, GB, vol. 119, no. 24, 1 December 2006 (2006-12-01), pages 5193 - 5203, XP002529576, ISSN: 0021-9533, DOI: 10.1242/JCS.03320
  • See references of WO 2015139047A2

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2015139047 A2 20150917; WO 2015139047 A3 20151210; CA 2941140 A1 20150917; EP 3116996 A2 20170118; EP 3116996 A4 20180110

DOCDB simple family (application)

US 2015020786 W 20150316; CA 2941140 A 20150316; EP 15760904 A 20150316