EP 3119882 A4 20170816 - METHODS FOR PRODUCING RECOMBINANT GLYCOPROTEINS WITH MODIFIED GLYCOSYLATION
Title (en)
METHODS FOR PRODUCING RECOMBINANT GLYCOPROTEINS WITH MODIFIED GLYCOSYLATION
Title (de)
VERFAHREN ZUR HERSTELLUNG VON REKOMBINANTEN GLYCOPROTEINEN MIT MODIFIZIERTER GLYCOSYLIERUNG
Title (fr)
PROCÉDÉS DE PRODUCTION DE GLYCOPROTÉINES RECOMBINÉES PRÉSENTANT UNE GLYCOSYLATION MODIFIÉE
Publication
Application
Priority
- US 201461954337 P 20140317
- IB 2015001203 W 20150317
Abstract (en)
[origin: US2015259720A1] Genetically engineered host animal cells capable of producing glycoproteins having modified glycosylation patterns, e.g., defucosylation and/or monoglycosylation. Such host animal cells can be engineered to express fucosidase, endoglycosidase or both.
IPC 8 full level
C12N 5/10 (2006.01); C07K 16/00 (2006.01); C07K 16/28 (2006.01); C07K 16/42 (2006.01); C12N 9/24 (2006.01); C12N 15/56 (2006.01); C12N 15/85 (2006.01); C12P 21/00 (2006.01)
CPC (source: EP IL KR US)
C07K 16/00 (2013.01 - IL US); C07K 16/2887 (2013.01 - EP IL KR US); C07K 16/4291 (2013.01 - EP IL KR US); C12N 9/2402 (2013.01 - EP IL US); C12N 9/2405 (2013.01 - EP IL KR US); C12N 15/85 (2013.01 - KR); C12P 21/005 (2013.01 - EP IL KR US); C12Y 302/01051 (2013.01 - EP IL KR US); C12Y 302/01096 (2013.01 - EP IL KR US); C07K 2317/14 (2013.01 - EP IL KR US); C07K 2317/41 (2013.01 - EP IL KR US); Y02P 20/52 (2015.11 - US)
Citation (search report)
- [XY] EP 2141237 A1 20100106 - MOGAM BIOTECH RES INST [KR]
- [IY] WO 2008071418 A2 20080619 - HANSA MEDICAL AB, et al
- [A] WO 9954342 A1 19991028 - UMANA PABLO [CH], et al
- [A] GERDES C A ET AL: "GA201 (RG7160): a novel, humanized, glycoengineered anti-EGFR antibody with enhanced ADCC and superior in vivo efficacy compared with cetuximab", CLINICAL CANCER RESEARCH, THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 19, no. 5, 1 March 2013 (2013-03-01), pages 1126 - 1138, XP002713826, ISSN: 1078-0432, [retrieved on 20121203], DOI: 10.1158/1078-0432.CCR-12-0989
- [A] FERRARA CLAUDIA ET AL: "MODULATION OF THERAPEUTIC ANTIBODY EFFECTOR FUNCTIONS BY GLYCOSYLATION ENGINEERING: INFLUENCE OF GOLGI ENZYME LOCALIZATION DOMAIN AND CO-EXPRESSION OF HETEROLOGOUS BETA 1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE III AND GOLGI ALPHA-MANNOSIDASE II", BIOTECHNOLOGY AND BIOENGINEE, WILEY ETC, vol. 93, no. 5, 5 April 2006 (2006-04-05), pages 851 - 861, XP009082743, ISSN: 0006-3592, DOI: 10.1002/BIT.20777
- See references of WO 2015145268A2
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
US 2015259720 A1 20150917; US 9540673 B2 20170110; AU 2015237951 A1 20161020; AU 2015237951 B2 20210701; BR 112016021284 A2 20171003; CA 2942618 A1 20151001; CN 106715686 A 20170524; CN 106715686 B 20210316; DK 3119882 T3 20220131; EP 3119882 A2 20170125; EP 3119882 A4 20170816; EP 3119882 B1 20211117; ES 2904993 T3 20220406; HU E057904 T2 20220628; IL 247776 A0 20161130; IL 247776 B 20210531; JP 2017507664 A 20170323; JP 2020072667 A 20200514; JP 6701089 B2 20200527; KR 102333923 B1 20211202; KR 20160127830 A 20161104; MX 2016012085 A 20170523; PL 3119882 T3 20220516; PT 3119882 T 20220120; RU 2016140528 A 20180417; RU 2016140528 A3 20181018; RU 2704830 C2 20191031; SG 11201607759R A 20161028; TW 201623620 A 20160701; TW I682033 B 20200111; US 10745729 B2 20200818; US 2017145463 A1 20170525; WO 2015145268 A2 20151001; WO 2015145268 A3 20160121; WO 2015145268 A8 20151203
DOCDB simple family (application)
US 201514660011 A 20150317; AU 2015237951 A 20150317; BR 112016021284 A 20150317; CA 2942618 A 20150317; CN 201580022914 A 20150317; DK 15770138 T 20150317; EP 15770138 A 20150317; ES 15770138 T 20150317; HU E15770138 A 20150317; IB 2015001203 W 20150317; IL 24777616 A 20160912; JP 2016558039 A 20150317; JP 2019222037 A 20191209; KR 20167028632 A 20150317; MX 2016012085 A 20150317; PL 15770138 T 20150317; PT 15770138 T 20150317; RU 2016140528 A 20150317; SG 11201607759R A 20150317; TW 104108376 A 20150316; US 201615358497 A 20161122