Global Patent Index - EP 3130678 A1

EP 3130678 A1 20170215 - IN-VITRO METHODS FOR THE DETECTION OF TREG RESISTANCE AND AUTOIMMUNE DISEASES

Title (en)

IN-VITRO METHODS FOR THE DETECTION OF TREG RESISTANCE AND AUTOIMMUNE DISEASES

Title (de)

IN-VITRO-VERFAHREN ZUM NACHWEIS VON RESISTENTEN REGULATORISCHEN T-ZELLEN UND AUTOIMMUNKRANKHEITEN

Title (fr)

PROCÉDÉS IN VITRO POUR LA DÉTECTION DES CELLULES T RÉGULATRICES ÉTANT RÉSISTANTES ET DES MALADIES AUTO-IMMUNES

Publication

EP 3130678 A1 20170215 (EN)

Application

EP 15180501 A 20150811

Priority

EP 15180501 A 20150811

Abstract (en)

The present invention relates to a method for the detection of impaired responsiveness of CD4+ T-cells to regulatory T-cells (Treg), referred to as Treg resistance, by measuring the expression levels of peroxisome proliferator-activated receptor gamma coactivator 1-alpha, PPARGC1A (PGC-1±) in activated CD4+ T-cells, in particular in patients with relapsing remitting multiple sclerosis. Furthermore, the invention relates to an in vitro screening method for the detection of an autoimmune disease or a condition, comprising the steps of generating a functional gene expression profile by measuring the expression levels of peroxisome proliferator-activated receptor gamma coactivator 1-alpha, PPARGC1 A (PGC-1±) in Treg-resistant CD4+ T-cells from patients suffering of an autoimmune disease or condition, and comparing the obtained gene expression profile with the expression profile from Treg-sensitive CD4+ T-cells from healthy controls. PCG-1± or an upstream regulator of Treg-resistant T-cells HNF4A, Hdac, RORA, ESRRA, LPIN1 can be used in a screening system for the detection of impaired responsiveness of CD4+ T-cells to Treg.

IPC 8 full level

C12Q 1/6883 (2018.01); G01N 33/53 (2006.01)

CPC (source: EP US)

C12Q 1/6883 (2013.01 - EP US); G01N 33/564 (2013.01 - EP US); G01N 33/56972 (2013.01 - EP US); C12Q 2600/106 (2013.01 - EP US); C12Q 2600/112 (2013.01 - EP US); C12Q 2600/158 (2013.01 - US); G01N 2333/70514 (2013.01 - EP US)

Citation (applicant)

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Citation (search report)

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Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

DOCDB simple family (publication)

EP 3130678 A1 20170215; EP 3130678 B1 20190220; CA 2993735 A1 20170216; CA 2993735 C 20230221; ES 2727433 T3 20191016; JP 2018522573 A 20180816; JP 6846408 B2 20210324; US 11447825 B2 20220920; US 2018216186 A1 20180802; WO 2017025533 A1 20170216

DOCDB simple family (application)

EP 15180501 A 20150811; CA 2993735 A 20160809; EP 2016068949 W 20160809; ES 15180501 T 20150811; JP 2018506934 A 20160809; US 201615747380 A 20160809